Journal article
An Ultrasound Enhancing Agent with Nonlinear Acoustic Activity that Depends on the Presence of an Electric Field
Ultrasound in medicine & biology, v 46(9), pp 2370-2387
Sep 2020
PMID: 32616427
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The nonlinear acoustic properties of microbubble ultrasound enhancing agents have allowed for the development of subharmonic, second harmonic, and contrast-pulse sequence ultrasound imaging modes, which enhance the quality, reduce the noise, and improve the diagnostic capabilities of clinical ultrasound. This study details acoustic scattering responses of perfluorobutane (PFB) microbubbles, an un-nested perfluoropentane (PFP) nanoemulsion, and two nested PFP nanoemulsions—one comprising a negatively charged phospholipid bilayer and another comprising a zwitterionic phospholipid bilayer—when excited at 1 or 2.25 MHz over a peak negative pressure range of 200 kPa to 4 MPa in the absence and presence of a 1-Hz, 1-V/cm electric field. The only sample that exhibited an increase in nonlinear activity in the presence of an electric field at both excitation frequencies was the negatively charged nested PFP nanoemulsion; the most pronounced effect was observed at an excitation of 2.25 MHz. Interestingly, the application of an electric field not only increased the nonlinear acoustic activity of the negatively charged nested PFP nanoemulsion but increased it beyond that seen when the nanoemulsion is un-nested and on the same scale as PFB microbubbles.
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Details
- Title
- An Ultrasound Enhancing Agent with Nonlinear Acoustic Activity that Depends on the Presence of an Electric Field
- Creators
- Michael Cimorelli - Drexel UniversityMichael A. Flynn - Drexel UniversityBrett Angel - Drexel UniversityAaron Fafarman - Drexel UniversityAndrew Kohut - University of PennsylvaniaSteven Wrenn - Drexel University
- Publication Details
- Ultrasound in medicine & biology, v 46(9), pp 2370-2387
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000558591200002
- Scopus ID
- 2-s2.0-85087219959
- Other Identifier
- 991019168734604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging