Journal article
An Uncommon Presentation of a Primary Bone Tumor: Anti-AMPA (Anti-α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic acid) Receptor Limbic/Paraneoplastic Encephalitis as a Presenting Feature of Ewing Sarcoma
Journal of pediatric hematology/oncology, v 40(7), pp 555-557
Oct 2018
PMID: 30247289
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Anti-AMPA (anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor limbic encephalitis is a rare autoimmune syndrome. It can be associated with an underlying malignancy, such as lung, breast, or thymus. We are reporting a case of a 19-year-old patient who presented with a 2-week history of confusion and short-term memory loss. A magnetic resonance imaging of brain showed increased T2 hyperintensity within the hippocampi bilaterally. Cerebrospinal fluid analysis was positive for anti-AMPA receptor antibodies. A computed tomography revealed multiple pulmonary metastases as well as an expansile lucent and sclerotic lesion in the ilium, which was subsequently biopsied. Histopathology confirmed a diagnosis of Ewing sarcoma (ES). Fluorescence in situ hybridization testing of the specimen identified EWSR1 (22q12.2) signal rearrangements in 80% of cells scored. To date, this is the first case report describing anti-AMPA receptor limbic/paraneoplastic encephalitis as a presenting feature of ES. Although it is rare, the possibility of ES may be considered in young patients presenting with anti-AMPA receptor limbic encephalitis.
Metrics
Details
- Title
- An Uncommon Presentation of a Primary Bone Tumor: Anti-AMPA (Anti-α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic acid) Receptor Limbic/Paraneoplastic Encephalitis as a Presenting Feature of Ewing Sarcoma
- Creators
- Daniel Koh - Department of Diagnostic Imaging, Monash HealthTheodore Lau - Department of Diagnostic Imaging, Gold Coast University Hospital, Qld, AustraliaEvonne Teoh - Department of Diagnostic Imaging, Monash HealthKenneth K Lau - Faculty of Medicine, Nursing and Health Sciences, Monash University, Vic
- Publication Details
- Journal of pediatric hematology/oncology, v 40(7), pp 555-557
- Publisher
- Lippincott; United States
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000446191900031
- Scopus ID
- 2-s2.0-85054142745
- Other Identifier
- 991014877884704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Hematology
- Oncology
- Pediatrics