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Journal article
An Unusual Case of Pulmonary Cryptococcus
Curēus (Palo Alto, CA), v 10(12), pe3707
01 Dec 2018
PMID: 30788196
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cryptococcal infections are caused by encapsulated fungi Cryptococcus gattii and C. neoformans. Inhalation commonly causes innocuous colonization but may cause meningitis or disseminated disease via hematogenous spread. Cryptococcosis occurs most commonly in immunocompromised patients including those with acquired immunodeficiency syndrome, meningoencephalitis or disseminated disease. However, cryptococcosis can occur as asymptomatic isolated pulmonary nodules in immunocompetent patients. Here we present a unique retrospective case report of a 55-year-old immunocompetent man who presented with pleuritic chest pain, productive cough, dyspnea on exertion, chills, night sweats, and weight loss. A computed tomography scan of his chest revealed multiple ground-glass opacities throughout both lung fields. The results of his autoimmune evaluation and human immunodeficiency virus tests were negative. A biopsy obtained through video-assisted thoracoscopic surgery revealed mucicarmine staining capsules confirming Cryptococcus, requiring treatment with amphotericin, flucytosine, and fluconazole. This case highlights the rarely studied presentation of symptomatic diffuse pulmonary cryptococcal infection in an immunocompetent patient requiring treatment.
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Details
- Title
- An Unusual Case of Pulmonary Cryptococcus
- Creators
- Hafiz M. Aslam - Seton Hall UniversityKelly A. Cann - Drexel UniversityKareem H. Genena - St. Francis Medical CenterSyed A. Akhtar Trimizi - Seton Hall UniversityMustansir A. Mir - Seton Hall UniversitySara L. Wallach - Seton Hall UniversityHerbert Conaway - Seton Hall UniversityMarc Seelagy - Seton Hall University
- Publication Details
- Curēus (Palo Alto, CA), v 10(12), pe3707
- Publisher
- Cureus Inc
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000461069500013
- Other Identifier
- 991019167872604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, General & Internal