Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke
Nature neuroscience, v 13(12), pp 1496-1504
01 Dec 2010
PMID: 21057507
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Stroke is an age-related disease. Recovery after stroke is associated with axonal sprouting in cortex adjacent to the infarct. The molecular program that induces a mature cortical neuron to sprout a new connection after stroke is not known. We selectively isolated neurons that sprout a new connection in cortex after stroke and compared their whole-genome expression profile to that of adjacent, non-sprouting neurons. This 'sprouting transcriptome' identified a neuronal growth program that consists of growth factor, cell adhesion, axonal guidance and cytoskeletal modifying molecules that differed by age and time point. Gain and loss of function in three distinct functional classes showed new roles for these proteins in epigenetic regulation of axonal sprouting, growth factor-dependent survival of neurons and, in the aged mouse, paradoxical upregulation of myelin and ephrin receptors in sprouting neurons. This neuronal growth program may provide new therapeutic targets and suggest mechanisms for age-related differences in functional recovery.
Metrics
Details
- Title
- An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke
- Creators
- Songlin Li - Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USAJustine J. Overman - Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USADiana Katsman - Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USASerguei V. Kozlov - NCI, Canc & Dev Biol Lab, Frederick, MD 21701 USAChristopher J. Donnelly - Drexel UniversityJeffery L. Twiss - Drexel UniversityRoman J. Giger - Univ Michigan, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USAGiovanni Coppola - University of California, Los AngelesDaniel H. Geschwind - Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USAS. Thomas Carmichael - Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA
- Publication Details
- Nature neuroscience, v 13(12), pp 1496-1504
- Publisher
- Springer Nature
- Number of pages
- 11
- Grant note
- R01NS049041 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Dr. Miriam and Sheldon G. Adelson Medical Research Foundation NS045729; NS04733; NS049041; AHA 09SDG2310180; 0525144Y / US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Larry L Hillblom Foundation US Department of Veterans Affairs American Federation of Aging Research
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000284525800014
- Scopus ID
- 2-s2.0-78649339985
- Other Identifier
- 991021892106804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences