Journal article
An architecture for the fusion site of Influenza hemagglutinin
FEBS letters, v 276(1), pp 1-5
1990
PMID: 2265687
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The recent finding that more than one Influenza hemagglutinin (HA) is required at the fusion site for HA-expressing fibroblasts [1], together with the crystal structure of HA at neutral pH [2], provide the basic elements of a plausible model for this fusion site. Within an aggregate of HA trimers at low pH, we propose fusion intermediates which are based upon a minimal alteration to the known neutral pH structure of HA and which should have reasonable activation energies. This is the first model of a glycoprotein-mediated fusion site which explicitly accounts for the disposition of the lipids within these intermediates. While the fusion site created by HA will not be the same as that of eukaryotic fusion complexes [3], general characteristics could be shared.
Metrics
Details
- Title
- An architecture for the fusion site of Influenza hemagglutinin
- Creators
- Joe Bentz - Drexel UniversityHarma Ellens - New FrontierDennis Alford - Drexel University
- Publication Details
- FEBS letters, v 276(1), pp 1-5
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; [Retired Faculty]
- Web of Science ID
- WOS:A1990EP34200001
- Scopus ID
- 2-s2.0-0025639178
- Other Identifier
- 991019173806204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics
- Cell Biology