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An atlas of B-cell clonal distribution in the human body
Journal article   Open access   Peer reviewed

An atlas of B-cell clonal distribution in the human body

Wenzhao Meng, Bochao Zhang, Gregory W Schwartz, Aaron M Rosenfeld, Daqiu Ren, Joseph J C Thome, Dustin J Carpenter, Nobuhide Matsuoka, Harvey Lerner, Amy L Friedman, …
Nature biotechnology, v 35(9), pp 879-886
Sep 2017
PMID: 28829438
url
https://europepmc.org/articles/pmc5679700View
Accepted (AM)Open Access (License Unspecified) Open

Abstract

Adult B-Lymphocytes - cytology Cell Lineage - genetics Clone Cells Female Humans Male Middle Aged Organ Specificity - genetics Young Adult
B-cell responses result in clonal expansion, and can occur in a variety of tissues. To define how B-cell clones are distributed in the body, we sequenced 933,427 B-cell clonal lineages and mapped them to eight different anatomic compartments in six human organ donors. We show that large B-cell clones partition into two broad networks-one spans the blood, bone marrow, spleen and lung, while the other is restricted to tissues within the gastrointestinal (GI) tract (jejunum, ileum and colon). Notably, GI tract clones display extensive sharing of sequence variants among different portions of the tract and have higher frequencies of somatic hypermutation, suggesting extensive and serial rounds of clonal expansion and selection. Our findings provide an anatomic atlas of B-cell clonal lineages, their properties and tissue connections. This resource serves as a foundation for studies of tissue-based immunity, including vaccine responses, infections, autoimmunity and cancer.

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This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Biotechnology & Applied Microbiology
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