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Accepted (AM)Open Access (License Unspecified), Open
Journal article
An atlas of B-cell clonal distribution in the human body
Nature biotechnology, v 35(9), pp 879-886
Sep 2017
PMID: 28829438
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
B-cell responses result in clonal expansion, and can occur in a variety of tissues. To define how B-cell clones are distributed in the body, we sequenced 933,427 B-cell clonal lineages and mapped them to eight different anatomic compartments in six human organ donors. We show that large B-cell clones partition into two broad networks-one spans the blood, bone marrow, spleen and lung, while the other is restricted to tissues within the gastrointestinal (GI) tract (jejunum, ileum and colon). Notably, GI tract clones display extensive sharing of sequence variants among different portions of the tract and have higher frequencies of somatic hypermutation, suggesting extensive and serial rounds of clonal expansion and selection. Our findings provide an anatomic atlas of B-cell clonal lineages, their properties and tissue connections. This resource serves as a foundation for studies of tissue-based immunity, including vaccine responses, infections, autoimmunity and cancer.
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Details
- Title
- An atlas of B-cell clonal distribution in the human body
- Creators
- Wenzhao Meng - University of PennsylvaniaBochao Zhang - Drexel UniversityGregory W Schwartz - Drexel UniversityAaron M Rosenfeld - Drexel UniversityDaqiu Ren - University of PennsylvaniaJoseph J C Thome - Columbia University Medical CenterDustin J Carpenter - Columbia University Medical CenterNobuhide Matsuoka - Columbia University Medical CenterHarvey Lerner - LiveOnNY, New York, New York, USA.Amy L Friedman - LiveOnNY, New York, New York, USA.Tomer Granot - Columbia University Medical CenterDonna L Farber - Columbia University Medical CenterMark J Shlomchik - University of PittsburghUri Hershberg - Drexel UniversityEline T Luning Prak - Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Publication Details
- Nature biotechnology, v 35(9), pp 879-886
- Publisher
- Springer Nature
- Grant note
- P30 CA016520 / NCI NIH HHS P01 AI106697 / NIAID NIH HHS F31 AG047003 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000410371600023
- Scopus ID
- 2-s2.0-85029311875
- Other Identifier
- 991019167809204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology