Journal article
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
Nov 2019
Abstract
Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; ncontrol = 13; nAD = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC). Using this and an independent (Mount Sinai Brain Bank (MSBB)) AD RNA-seq dataset, cortical circular RNA (circRNA) expression was quantified in the context of AD. Significant associations were identified between circRNA expression and AD diagnosis, clinical dementia severity and neuropathological severity. It was demonstrated that most circRNA–AD associations are independent of changes in cognate linear messenger RNA expression or estimated brain cell-type proportions. Evidence was provided for circRNA expression changes occurring early in presymptomatic AD and in autosomal dominant AD. It was also observed that AD-associated circRNAs co-expressed with known AD genes. Finally, potential microRNA-binding sites were identified in AD-associated circRNAs for miRNAs predicted to target AD genes. Together, these results highlight the importance of analyzing non-linear RNAs and support future studies exploring the potential roles of circRNAs in AD pathogenesis.
Metrics
1 Record Views
Details
- Title
- An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
- Creators
- U DubeJ L Del-AguilaZ LiJ P BuddeS JiangS HsuL IbanezM V FernandezF FariasJ NortonJ GentschF WangS SallowayC L MastersJ-H LeeN R Graff-RadfordJ P ChhatwalR J BatemanJ C MorrisC M KarchO HarariC CruchagaR AllegriF AmtasharT BenzingerS BermanC BodgeS BrandonW BrooksJ BuckV BucklesS CheaP ChremH ChuiJ CincoJ CliffordM D'MelloT DonahueJ DouglasN EdigoN Erekin-TanerA FaganM FarlowA FarrarH FeldmanG FlynnN FoxE FranklieH FujiiC GantS GardenerB GhettiA GoateJ GoldmanB GordonJ GrayJ GurneyJ HassenstabM HiroharaD HoltzmanR HornbeckS H DiBariT IkeuchiS IkonomovicG JeromeM JuckerK KasugaT KawarabayashiW KlunkR KoeppeE Kuder-BulettaC LaskeJ LevinD MarcusR MartinsN S MasonD Maue-DreyfusE McDadeL MontoyaH MoriA NagamatsuK NeimeyerJ NobleR PerrinM RaichleJ RingmanJ H RohP SchofieldH ShimadaT ShirotoM ShojiW SigurdsonH SohrabiP SparksK SuzukiL SwisherK TaddeiJ WangP WangM WeinerM WolfsbergerC XiongX Xu
- Publisher
- NATURE PUBLISHING GROUP
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Emergency Medicine; [Retired Faculty]; Biochemistry and Molecular Biology
- Identifiers
- 991020202345804721