Journal article
An electronic device for artefact suppression in human local field potential recordings during deep brain stimulation
Journal of neural engineering, v 4(2)
01 Jun 2007
PMID: 17409484
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The clinical efficacy of high-frequency deep brain stimulation (DBS) for Parkinson's disease and other neuropsychiatric disorders likely depends on the modulation of neuronal rhythms in the target nuclei. This modulation could be effectively measured with local field potential (LFP) recordings during DBS. However, a technical drawback that prevents LFPs from being recorded from the DBS target nuclei during stimulation is the stimulus anefact. To solve this problem, we designed and developed 'FilterDBS', an electronic amplification system for artefact-free LFP recordings (in the frequency range 2-40 Hz) during DBS. After defining the estimated system requirements for LFP amplification and DBS anefact suppression, we tested the FilterDBS system by conducting experiments in vitro and in vivo in patients with advanced Parkinson's disease undergoing DBS of the subthalamic nucleus (STN). Under both experimental conditions, in vitro and in vivo, the FilterDBS system completely suppressed the DBS artefact without inducing significant spectral distortion. The FilterDBS device pioneers the development of an adaptive DBS system retroacted by LFPs and can be used in novel closed-loop brain-machine interface applications in patients with neurological disorders.
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Details
- Title
- An electronic device for artefact suppression in human local field potential recordings during deep brain stimulation
- Creators
- L. Rossi - Ospedale MaggioreG. Foffani - Drexel UniversityS. Marceglia - Ospedale MaggioreF. Bracchi - University of MilanS. Barbieri - Ospedale MaggioreA. Priori
- Publication Details
- Journal of neural engineering, v 4(2)
- Publisher
- Iop Publishing Ltd
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000247947300016
- Scopus ID
- 2-s2.0-34247231076
- Other Identifier
- 991019353625204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Neurosciences