Journal article
An experimental test of stroke recovery by implanting a hyaluronic acid hydrogel carrying a Nogo receptor antibody in a rat model
Biomedical materials (Bristol), v 2(4), pp 233-240
01 Dec 2007
PMID: 18458480
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The objective of the study was to determine the effects of a hyaluronic-acid-based (HA-based) hydrogel implant, carrying a polyclonal antibody to the Nogo-66 receptor (NgR), on adult rats that underwent middle cerebral artery occlusion (MCAO). Behavioral tests of a forelimb-reaching task suggested that the disabled function of the impaired forelimb in this stroke model was ameliorated by the implant to a certain extent. These behavioral findings were correlated with immunohistochemical results of investigating the distribution of NgR antibody, neurofilaments (NF) and neuron-specific class III beta-tubulin (TuJ1) in the brain sections. The porous hydrogel functioned as a scaffold to deliver the NgR antibody, support cell migration and development. In addition, it was found NF-positive and TuJ1-positive expressions were distributed in the implanted hydrogel. Collectively, the results demonstrate the promise of the HA hydrogel as a scaffold material and the delivery vehicle of the NgR antibody for the repair of defects and the support of neural regeneration in the brain.
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Details
- Title
- An experimental test of stroke recovery by implanting a hyaluronic acid hydrogel carrying a Nogo receptor antibody in a rat model
- Creators
- Jun Ma - Tsinghua UniversityWei-Ming Tian - Tsinghua UniversityShao-Ping Hou - Capital UniversityQun-Yuan Xu - Capital UniversityMyron Spector - VA Boston Healthcare SystemFu-Zhai Cui - Tsinghua University
- Publication Details
- Biomedical materials (Bristol), v 2(4), pp 233-240
- Publisher
- Iop Publishing Ltd
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; College of Medicine; Drexel University
- Web of Science ID
- WOS:000252969200008
- Scopus ID
- 2-s2.0-36749099509
- Other Identifier
- 991020100067004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials