Journal article
An extended Monod-Wyman-Changeaux-model expressed in terms of the Herzfeld-Stanley formalism applied to oxygen and carbonmonoxide binding curves of hemoglobin trout IV
Biophysical journal, v 55(4), pp 691-701
Apr 1989
PMID: 2720067
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Abstract
An extended Monod, Wyman, Changeaux (MWC)-model, the mathematical basis of which had been formulated by Herzfeld and Stanley (J. Mol. Blol. 82:231. 1974.) was used to fit oxygen and CO-binding curves of hemoglobin trout IV measured at different pH-values between pH = 8.0 and 6.0. From this calculation one obtains that even the fully liganded molecule exhibits a R---T quaternary transition upon approaching the acid pH-region. In the case of O2-binding, the cooperativity becomes negative below pH = 6.5. This can be related to the difference between the equilibrium constants of proton binding to the alpha- and beta-subunits. Furthermore, it can be shown that the interaction between the quaternary T---R- and the tertiary t---r-transitions is different for the alpha- and beta-subunits.
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Details
- Title
- An extended Monod-Wyman-Changeaux-model expressed in terms of the Herzfeld-Stanley formalism applied to oxygen and carbonmonoxide binding curves of hemoglobin trout IV
- Creators
- R Schweitzer-Stenner - University of BremenW Dreybrodt - University of Bremen
- Publication Details
- Biophysical journal, v 55(4), pp 691-701
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:A1989T872000012
- Scopus ID
- 2-s2.0-0024651305
- Other Identifier
- 991019196705704721
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- Web of Science research areas
- Biophysics