Journal article
An extended Monod-Wyman-Changeaux-model expressed in terms of the Herzfeld-Stanley formalism applied to oxygen and carbon monoxide binding curves of hemoglobin trout IV
Biophysical Journal, Vol.55(4), pp.691-701
01 Jan 1989
Abstract
An extended Monod, Wyman, Changeaux (MWC)-model was used to fit oxygen and CO-binding curves of hemoglobin trout IV measured at different pH-values between pH = 8.0 and 6.0. From this calculation one obtains that even the fully liganded molecule exhibits a R arrow right T quaternary transition upon approaching the acid pH-region. In the case of O sub(2)-binding, the cooperativity becomes negative below pH = 6.5. This can be related to the difference between the equilibrium constants of proton binding to the alpha - and beta -subunits.
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Details
- Title
- An extended Monod-Wyman-Changeaux-model expressed in terms of the Herzfeld-Stanley formalism applied to oxygen and carbon monoxide binding curves of hemoglobin trout IV
- Creators
- R Schweitzer-StennerW Dreybrodt
- Publication Details
- Biophysical Journal, Vol.55(4), pp.691-701
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Identifiers
- 991019196788104721