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An individualized approach to treatment for alzheimer's disease, pick's disease, and other dementias
Journal article   Open access   Peer reviewed

An individualized approach to treatment for alzheimer's disease, pick's disease, and other dementias

Carol F Lippa
American journal of Alzheimer's disease and other dementias, v 21(5), pp 354-359
Oct 2006
PMID: 17062555
url
https://doi.org/10.1177/1533317506292372View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze) Open

Abstract

Amyloid beta-Peptides - metabolism Cholinesterase Inhibitors - therapeutic use Dementia - drug therapy Dementia - genetics Dementia - metabolism Excitatory Amino Acid Antagonists - therapeutic use Humans Microarray Analysis
Treatment options for dementia are now available, and increasing numbers of individuals with cognitive disorders are being evaluated for intervention. Little effort is made to select patients who will benefit from the various treatments. Widespread use of medication places patients at risk for developing side effects, which is one reason to target patients likely to benefit from specific interventions. We have limited health care resources and a growing population of elderly individuals with dementia, so our current system of "hit or miss" intervention will become increasingly costly and inefficient. Selecting those likely to benefit from specific interventions would improve efficiency. This article reviews some current approaches for treating dementia and describes a strategy that may help predict which individuals will respond to specific dementia-related treatments. This individualized approach has potential to increase the beneficial effects of medications, reduce the likelihood of side effects, and preserve health care resources.

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