Journal article
An innovative tunable bimodal porous PCL/gelatin dressing fabricated by electrospinning and 3D printing for efficient wound healing and scalable production
Composites science and technology, v 247, 110402
01 Mar 2024
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study presents the development of tunable scaffolds with bimodal porosity comprising poly(e-caprolactone) (PCL) micro-meshes and PCL/gelatin/e-polylysine (e-PL) fibrous layers. Pure PCL scaffolds were prepared using the fused deposition modeling technique featuring grid geometry and interconnected micro-pores, followed by electrospinning to produce PCL/gelatin/e-PL nanofibrous layers. Field emission scanning electron microscopy was employed to investigate the morphological features of the scaffolds, while the physicomechanical properties were studied using tensile and contact angle tests. Antibacterial performance and skin cell toxicity of the scaffolds were determined by bacterial disc diffusion and cell viability assays, respectively. Morphological analysis showed the presence of micro-to nano-sized pores in the developed scaffolds. The mechanical test results revealed that the prepared scaffolds exhibited Young's modulus values similar to the human skin with higher strain. The nanocomposite scaffolds were cytocompatible and effectively eradicated common bacteria associated with cutaneous wounds. In light of the aforementioned results along with facile fabrication, the tunable PCL/ gelatin/e-PL porous scaffolds hold great promise for applications in skin wound repair.
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Details
- Title
- An innovative tunable bimodal porous PCL/gelatin dressing fabricated by electrospinning and 3D printing for efficient wound healing and scalable production
- Creators
- Erfan Rezvani Ghomi - Drexel University, A.J. Drexel Nanomaterials InstituteVijila Chellappan - Agency for Science, Technology and ResearchRasoul Esmaeely Neisiany - Silesian University of TechnologyNileshkumar Dubey - National University of SingaporeKottaiswamy Amuthavalli - Nanyang Technological UniversityNavin Kumar Verma - National Skin CentreRajamani Lakshminarayanan - National University of SingaporeSeeram Ramakrishna - National University of Singapore
- Publication Details
- Composites science and technology, v 247, 110402
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- Singapore International Graduate Award (SINGA) MOH-000963-00 / Open Funding-Independent Research Grant MOH-001001-00 / Singapore Ministry of Health's National Medical Research Council under its Centre Grant Program RG94/22 / Singapore Ministry of Education (MOE) under its MOE Academic Research Fund (AcRF) Tier 1 Grant Ruby Yu-Tong Lin for training him on 3D printing
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Nanomaterials Institute
- Web of Science ID
- WOS:001145243200001
- Scopus ID
- 2-s2.0-85180527487
- Other Identifier
- 991021861278504721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Materials Science, Composites