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An introduction to modeling interlocked molecule systems and application to a "molecular elevator"
Journal article

An introduction to modeling interlocked molecule systems and application to a "molecular elevator"

Karl Sohlberg and Ki-Ho Lee
Journal of computational and theoretical nanoscience, v 3(6), pp 865-873
01 Dec 2006

Abstract

Chemistry Chemistry, Multidisciplinary Materials Science Materials Science, Multidisciplinary Nanoscience & Nanotechnology Physical Sciences Physics Physics, Applied Physics, Condensed Matter Science & Technology Science & Technology - Other Topics Technology
A survey is presented of the various theoretical/computational methods that have been applied to interlocked molecule systems, with references to representative examples. We then apply a multiple-sampling and statistical analysis procedure of modeling switchable interlocked molecule systems to an experimentally-realized pH-switchable multiple rotaxane system that consists of three linked shafts threading three fused rings. The calculations successfully recover the experimentally observed co-conformational preference as a function of the degree of protonation. The results provide an explanation for the observation that the switching of the fused rings along the trio of shafts occurs by sequential (as opposed to concerted) ring movement. A proposed modification of the system to increase the amplitude of ring shuttling is advanced and supported by electronic structure calculations.

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31 citations in Scopus

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Web of Science research areas
Chemistry, Multidisciplinary
Materials Science, Multidisciplinary
Nanoscience & Nanotechnology
Physics, Applied
Physics, Condensed Matter
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