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An old problem with new solutions: Strategies to improve vaccine efficacy in the elderly
Journal article   Peer reviewed

An old problem with new solutions: Strategies to improve vaccine efficacy in the elderly

Matthew R. Bell and Michele A. Kutzler
Advanced drug delivery reviews, v 183, 114175
Apr 2022
DOI: https://doi.org/10.1016/j.addr.2022.114175
PMID: 35202770
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Adaptive immunity Adjuvant Age Clostridioides difficile Elderly Inflammaging Influenza Innate immunity mRNA vaccine SARS-CoV-2 Vaccination Varicella Zoster
[Display omitted] Vaccination is the most effective measure to protect against infections. However, with increasing age, there is a progressive decline in the ability of the immune system to both protect against infection and develop protective immunity from vaccination. This age-related decline of the immune system is due to age-related changes in both the innate and adaptive immune systems. With an aging world population and increased risk of pandemics, there is a need to continue to develop strategies to increase vaccine responses in the elderly. Here, the major age-related changes that occur in both the innate and adaptive immune responses that impair the response to vaccination in the elderly will be highlighted. Existing and future strategies to improve vaccine efficacy in the elderly will then be discussed, including adjuvants, delivery methods, and formulation. These strategies provide mechanisms to improve the efficacy of existing vaccines and develop novel vaccines for the elderly.

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18 Record Views
21 citations in Web of Science
19 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Web of Science research areas
Pharmacology & Pharmacy
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