Journal article
An orexigenic role for mu-opioid receptors in the lateral parabrachial nucleus
American journal of physiology. Regulatory, integrative and comparative physiology, v 285(5), pp R1055-R1065
Nov 2003
PMID: 14557237
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The pontine parabrachial nucleus (PBN) has been implicated in regulating ingestion and contains opioids that promote feeding elsewhere in the brain. We tested the actions of the selective mu-opioid receptor (mu-OR) agonist [d-Ala2,N-Me-Phe4,Gly5-ol]enkephalin (DAMGO) in the PBN on feeding in male rats with free access to food. Infusing DAMGO (0.5-4.0 nmol/0.5 microl) into the lateral parabrachial region (LPBN) increased food intake. The hyperphagic effect was anatomically specific to infusions within the LPBN, dose and time related, and selective for ingestion of chow compared with (nonnutritive) kaolin. The nonselective opioid antagonist naloxone (0.1-10.0 nmol intra-PBN) antagonized DAMGO-induced feeding, with complete blockade by 1.0 nmol and no effect on baseline. The highly selective mu-opioid antagonist d-Phe-Cys-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP; 1.0 nmol) also prevented this action of DAMGO, but the kappa-antagonist nor-binaltorphimine did not. Naloxone and CTAP (10.0 nmol) decreased intake during scheduled feeding. Thus stimulating mu-ORs in the LPBN increases feeding, whereas antagonizing these sites inhibits feeding. Together, our results implicate mu-ORs in the LPBN in the normal regulation of food intake.
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Details
- Title
- An orexigenic role for mu-opioid receptors in the lateral parabrachial nucleus
- Creators
- John D Wilson - Dept. of Pharmacology and Physiology, Drexel Univ. College of Medicine, Mailstop 488, 245 N. 15th St., Philadelphia, PA 19102-1192, USADanielle M NicklousVincent J AloyoKenny J Simansky
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, v 285(5), pp R1055-R1065
- Publisher
- American Physiological Society (APS); United States
- Grant note
- R01 DK058669 / NIDDK NIH HHS R01 MH041987 / NIMH NIH HHS DK-58669 / NIDDK NIH HHS MH-41987 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000185908200019
- Scopus ID
- 2-s2.0-0142031647
- Other Identifier
- 991014878301504721
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- Web of Science research areas
- Physiology