Journal article
Analysis of gene expression in carbon tetrachloride-treated rat livers using a novel bioarray technology
The pharmacogenomics journal, v 3(1)
10 Mar 2003
PMID: 12629582
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The present study successfully utilizes a new ADME Rat Expression Bioarray, containing 1040 metabolism- and toxicology-linked genes, to monitor gene expression from the livers of rats treated with carbon tetrachloride (CCl(4)). Histopathological analysis, hierarchical clustering methods, and gene expression profiling are compared between the control and CCl(4)-treated animals. A total of 44 transcripts were found to be altered in response to the hepatotoxin, 19 of which were upregulated and 25 were downregulated. Some of these gene expression changes were expected and concurred with previously published data while others were novel findings.
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Details
- Title
- Analysis of gene expression in carbon tetrachloride-treated rat livers using a novel bioarray technology
- Creators
- M B Young - Motorola Life Sciences (United States, Northbrook)M R DiSilvestro - TissueInformatics Inc (United States, Pittsburgh)T J Sendera (Corresponding Author) - Motorola Life Sciences (United States, Northbrook)J Freund - TissueInformatics Inc (United States, Pittsburgh)A Kriete - TissueInformatics Inc (United States, Pittsburgh)S R Magnuson - Motorola Life Sciences (United States, Northbrook)
- Publication Details
- The pharmacogenomics journal, v 3(1)
- Publisher
- Springer Nature; United States
- Number of pages
- 12
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000186452700009
- Scopus ID
- 2-s2.0-0037248319
- Other Identifier
- 991014877867204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Genetics & Heredity
- Pharmacology & Pharmacy