Journal article
Analysis of tablet compaction. I. Characterization of mechanical behavior of powder and powder/tooling friction
Journal of pharmaceutical sciences, v 93(8), pp 2022-2039
Aug 2004
PMID: 15236452
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In this first of two articles on the modeling of tablet compaction, the experimental inputs related to the constitutive model of the powder and the powder/tooling friction are determined. The continuum-based analysis of tableting makes use of an elasto-plastic model, which incorporates the elements of yield, plastic flow potential, and hardening, to describe the mechanical behavior of microcrystalline cellulose over the range of densities experienced during tableting. Specifically, a modified Drucker-Prager/cap plasticity model, which includes material parameters such as cohesion, internal friction, and hydrostatic yield pressure that evolve with the internal state variable relative density, was applied. Linear elasticity is assumed with the elastic parameters, Young's modulus, and Poisson's ratio dependent on the relative density. The calibration techniques were developed based on a series of simple mechanical tests including diametrical compression, simple compression, and die compaction using an instrumented die. The friction behavior is measured using an instrumented die and the experimental data are analyzed using the method of differential slices. The constitutive model and frictional properties are essential experimental inputs to the finite element-based model described in the companion article.
Metrics
Details
- Title
- Analysis of tablet compaction. I. Characterization of mechanical behavior of powder and powder/tooling friction
- Creators
- J C Cunningham - Merck Research Laboratories, Merck and Co., Inc., West Point, Pennsylvania 19486, USA. john_c_cunningham@merck.comI C SinkaA Zavaliangos
- Publication Details
- Journal of pharmaceutical sciences, v 93(8), pp 2022-2039
- Publisher
- Wiley; United States
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000223069700009
- Scopus ID
- 2-s2.0-3843107053
- Other Identifier
- 991014877709904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Multidisciplinary
- Pharmacology & Pharmacy