Journal article
Analysis of the DrexelMed HIV/AIDS cohort for envelope markers
Journal of neurovirology, Vol.13, pp.61-61
01 Jan 2007
Abstract
Microglial cells and perivascular macrophages support most productive HIV-1 replication within the brain, although both have low CD4 levels making macrophage tropism and preferential CCR5 utilization features of CNS-derived viruses/envelopes. Sequence analysis has demonstrated both viral evolution within the CNS and compartmentalization of sequences between brain and peripheral tissues, suggesting the potential for adaptation to replication in the brain environment. Previous studies of human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) have identified the 3T configuration of CCAAT enhancer binding protein C/EBP site I (C-to-T change at nucleotide position 3) and 5T configuration of Sp site III (C-to-T change at nucleotide position 5) to correlate with peripheral blood disease progression and HIV-associated dementia (HAD). The 3T/5T-containing LTR may be representative of an LTR genotype that is preferentially retained, because of specific functional properties involved in disease pathogenesis, in the PB, CNS, and perhaps other compartments as HIV-1-associated disease severity increases suggesting that it may be useful as a predictive viral marker. In addition, we propose certain envelope sequences are co-selected with this LTR, which play a key role in cell types infected within the peripheral blood and. Herein, we present an analysis of the DrexelMed HIV/AIDS cohort for the presence of specific configurations of HIV-1 LTR transcription factor binding sites in association with specific envelope genotypes. Future studies will address functional properties of these viral genetic signatures.
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Details
- Title
- Analysis of the DrexelMed HIV/AIDS cohort for envelope markers
- Creators
- B AiamkitsumritK FlaigB IrishE KilareskiM NonnemacherJ Martin-GarciaB Wigdahl
- Publication Details
- Journal of neurovirology, Vol.13, pp.61-61
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Identifiers
- 991019170117704721