Journal article
Analysis of the cytolytic T-lymphocyte response to herpes simplex virus type 1 glycoprotein B during primary and secondary infection
Journal of virology, v 68(11), pp 7644-7648
Nov 1994
PMID: 7933156
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The immune response to herpes simplex virus type 1 (HSV-1) infection in C57BL/6 mice includes a population of major histocompatibility complex class I-restricted cytolytic T lymphocytes (CTL) that recognize the structural glycoprotein gB. To gain insight into the importance of this CTL subpopulation in vivo, gB-specific CTL present in the regional lymph nodes after a primary infection and after a reinfection of convalescent animals were analyzed. In a primary infection, gB-specific CTL precursors (CTLp) that recognized either a cell line constitutively expressing gB or cells pulsed with the optimal Kb-restricted gB epitope 498SSIEFARL505 were present at an estimated frequency of 1/12,000 compared with a frequency of 1/3,000 for CTLp which recognized cells infected with HSV-1 itself. In convalescent mice responding to reinfection, HSV-specific CTLp were present at an estimated frequency of 1/4,000 to 1/14,000. However, gB-specific CTLp could not be detected at this site. These findings suggest that CTL specific for an immunodominant epitope contribute substantially to the primary response but may not be a component of the HSV-specific CTL population that responds rapidly to reinfection in vivo.
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Details
- Title
- Analysis of the cytolytic T-lymphocyte response to herpes simplex virus type 1 glycoprotein B during primary and secondary infection
- Creators
- C T Nugent - Department of Microbiology and Immunology, Louisiana State University Medical Center, Shreveport 71130R M Wolcott - Department of Microbiology and Immunology, Louisiana State University Medical Center, Shreveport 71130R Chervenak - Department of Microbiology and Immunology, Louisiana State University Medical Center, Shreveport 71130S R Jennings - Department of Microbiology and Immunology, Louisiana State University Medical Center, Shreveport 71130
- Publication Details
- Journal of virology, v 68(11), pp 7644-7648
- Publisher
- American Society for Microbiology (ASM)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1994PL73600100
- Scopus ID
- 2-s2.0-0028033008
- Other Identifier
- 991014877896804721
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- Web of Science research areas
- Virology