Journal article
Anaplastic glioneuronal tumor with KIAA1549/BRAF fusion
Intractable and rare disease research, v 8(4), pp 279-282
01 Nov 2019
PMID: 31890457
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Glioneuronal tumors are usually low-grade and have favorable prognosis. The anaplastic glioneuronal tumor with
KIAA1549/BRAF
fusion has not yet been documented. This article reports a case of glioneuronal tumor with anaplasia and
KIAA1549/BRAF
fusion to illuminate the importance of
KIAA1549/BRAF
fusion in high-grade glioneuronal tumors. A ten-year-old boy presented with one year of headache and three months of blurry vision and proptosis. Ophthalmologic evaluation revealed bilateral papilledema. Magnetic resonance imaging showed a large mixed cystic and solid mass in the left frontal lobe of cerebrum. Histologic analysis demonstrated a neoplasm with pseudopapillary growth pattern, focal necrosis, microcalcification, and brisk mitotic activity with a high Ki67 labeling index of focally up to 20%. Immunohistochemical assessment identified a mixed glial and neuronal neoplastic cell population. Molecular studies revealed a
KIAA1549/BRAF
fusion. The histological and molecular changes are consistent with an anaplastic glioneuronal tumor with
KIAA1549/BRAF
fusion. In view of the fact that the effective, targeted therapies for the tumors with
KIAA1549/BRAF
fusion are available, detection of
KIAA1549/BRAF
fusion for high-grade glioneuronal tumors is clinically helpful.
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1 citations in Scopus
Details
- Title
- Anaplastic glioneuronal tumor with KIAA1549/BRAF fusion
- Creators
- Liqiong Liu - Rutgers, The State University of New JerseyPrithvi Narayan - Johnson UniversityJay Xiong - University of California, BerkeleyZhenggang Xiong - Rutgers, The State University of New Jersey
- Publication Details
- Intractable and rare disease research, v 8(4), pp 279-282
- Publisher
- International Research and Cooperation Association for Bio & Socio-Sciences Advancement
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; Neurosurgery
- Web of Science ID
- WOS:000503070500010
- Scopus ID
- 2-s2.0-85078976207
- Other Identifier
- 991021955155104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology