Journal article
Anaplastic thyroid cancer: Prognostic factors, patterns of care, and overall survival
Head & neck, v 38 Suppl 1(S1), pp E2083-E2090
Apr 2016
PMID: 26894506
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Anaplastic thyroid cancer (ATC) represents a rare, aggressive malignancy. We analyzed factors predictive for overall survival (OS) and treatment modality utilization.
Using the National Cancer Data Base, we identified 3552 patients with ATC. Factors associated with surgery, high-dose radiotherapy (RT; ≥59.4 Gy), and chemotherapy utilization were evaluated using multivariable logistic regression. From this, an inverse probability-weighted propensity score was incorporated into multivariable Cox regression analyses for OS.
Numerous factors predictive for high-dose RT, total thyroidectomy, and chemotherapy utilization are described. Factors associated with improved survival were absence of clinical or pathologic lymph node involvement, absence of metastasis, tumor size ≤6 cm, negative surgical margins, surgery, RT, and chemotherapy. On conditional landmark analysis, improved survival seen with chemotherapy and surgery other than total thyroidectomy was lost, but persisted for total thyroidectomy and high-dose RT.
Even after correction for selection and immortal time bias, high-dose RT resulted in improved survival. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2083-E2090, 2016.
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Details
- Title
- Anaplastic thyroid cancer: Prognostic factors, patterns of care, and overall survival
- Creators
- Scott M Glaser - UPMC Hillman Cancer CenterSteven F Mandish - Marshall UniversityBeant S Gill - UPMC Hillman Cancer CenterGoundappa K Balasubramani - University of PittsburghDavid A Clump - UPMC Hillman Cancer CenterSushil Beriwal - UPMC Hillman Cancer Center
- Publication Details
- Head & neck, v 38 Suppl 1(S1), pp E2083-E2090
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000375116400272
- Scopus ID
- 2-s2.0-84975745657
- Other Identifier
- 991021897395704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Otorhinolaryngology
- Surgery