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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Anatomic Magnetic Resonance Imaging of the Developing Child and Adolescent Brain and Effects of Genetic Variation
Neuropsychology review, v 20(4), pp 349-361
01 Dec 2010
PMCID: PMC3268519
PMID: 21069466
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Magnetic resonance imaging studies have begun to map effects of genetic variation on trajectories of brain development. Longitudinal studies of children and adolescents demonstrate a general pattern of childhood peaks of gray matter followed by adolescent declines, functional and structural increases in connectivity and integrative processing, and a changing balance between limbic/subcortical and frontal lobe functions, which extends well into young adulthood. Twin studies have demonstrated that genetic factors are responsible for a significant amount of variation in pediatric brain morphometry. Longitudinal studies have shown specific genetic polymorphisms affect rates of cortical changes associated with maturation. Although over-interpretation and premature application of neuroimaging findings for diagnostic purposes remains a risk, converging data from multiple imaging modalities is beginning to elucidate the influences of genetic factors on brain development and implications of maturational changes for cognition, emotion, and behavior.
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Details
- Title
- Anatomic Magnetic Resonance Imaging of the Developing Child and Adolescent Brain and Effects of Genetic Variation
- Creators
- Jay N. Giedd - NIMHMichael Stockman - National Institute of Mental HealthCatherine Weddle - National Institute of Mental HealthMaria Liverpool - National Institute of Mental HealthAaron Alexander-Bloch - National Institute of Mental HealthGregory L. Wallace - National Institute of Mental HealthNancy R. Lee - National Institute of Mental HealthFrancois Lalonde - NIMH, Child Psychiat Branch, Bethesda, MD 20892 USARhoshel K. Lenroot - National Institute of Mental Health
- Publication Details
- Neuropsychology review, v 20(4), pp 349-361
- Publisher
- Springer Nature
- Number of pages
- 13
- Grant note
- ZIAMH002794 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) National Institute of Mental Health, National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000284425000003
- Scopus ID
- 2-s2.0-79951674630
- Other Identifier
- 991019296578204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences
- Psychology, Clinical