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Journal article
Anatomical coupling among distributed cortical regions in youth varies as a function of individual differences in vocabulary abilities
Human brain mapping, v 35(5), pp 1885-1895
01 May 2014
PMID: 23728856
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Patient lesion and functional magnetic resonance imaging (fMRI) studies have provided convincing evidence that a distributed brain network subserves word knowledge. However, little is known about the structural correlates of this network within the context of typical development and whether anatomical coupling in linguistically relevant regions of cortex varies as a function of vocabulary skill. Here we investigate the association between vocabulary and anatomical coupling in 235 typically developing youth (ages 6-19 years) using structural MRI. The study's primary aim was to evaluate whether higher vocabulary performance was associated with greater vertex-level cortical thickness covariation in distributed regions of cortex known to be associated with word knowledge. Results indicate that better vocabulary skills are associated with greater anatomical coupling in several linguistically relevant regions of cortex, including the left inferior parietal (temporal-parietal junction), inferior temporal, middle frontal, and superior frontal gyri and the right inferior frontal and precentral gyri. Furthermore, in high vocabulary scorers, stronger coupling is found among these regions. Thus, complementing patient and fMRI studies, this is the first investigation to highlight the relevance of anatomical covariance within the cortex to vocabulary skills in typically developing youth, further elucidating the distributed nature of neural systems subserving word knowledge. Hum Brain Mapp 35:1885-1895, 2014. (c) 2013 Wiley Periodicals, Inc.
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Details
- Title
- Anatomical coupling among distributed cortical regions in youth varies as a function of individual differences in vocabulary abilities
- Creators
- Nancy Raitano Lee - National Institute of Mental HealthArmin Raznahan - National Institute of Mental HealthGregory L. Wallace - National Institute of Mental HealthAaron Alexander-Bloch - National Institute of Mental HealthLiv S. Clasen - National Institute of Mental HealthJason P. Lerch - University of TorontoJay N. Giedd - National Institute of Mental Health
- Publication Details
- Human brain mapping, v 35(5), pp 1885-1895
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- ZIAMH002794 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) National Institutes of Health, National Institute of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000334012100007
- Scopus ID
- 2-s2.0-84898038919
- Other Identifier
- 991019296800204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neuroimaging
- Neurosciences
- Radiology, Nuclear Medicine & Medical Imaging