Journal article
Anatomical evidence for multiple pathways leading from the rostral ventrolateral medulla (nucleus paragigantocellularis) to the locus coeruleus in rat
Neuroscience letters, v 118(2), pp 141-146
16 Oct 1990
PMID: 2274260
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Using retrograde transport of Fluoro-Gold (FG) combined with immuncfluorescence for phenylethanolamine-
N-methyltransferase (PNMT), we have examined afferents to the nucleus locus coeruleus (LC) from the rostral ventrolateral medulla (nucleus paragigantocellularis; PGi) in rats sustaining lesions of the medullary adrenergic bundle (MB). In lesioned rats, very few adrenergic LC-projecting neurons persist in the PGi ipsilateral to the lesion, representing a 90% decrease in comparison to non-lesioned animals. These results indicate that almost all adrenergic input to the LC from C1 neurons in PGi is conveyed by the MB. In contrast, the number of non-adrenergic LC afferent neurons in the PGi ipsilateral to the lesion only decreased by 48% after such lesions. Thus, this pathway also provides non-adrenergic projections to LC from PGi, but many of these are conveyed by other route(s) as well.
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Details
- Title
- Anatomical evidence for multiple pathways leading from the rostral ventrolateral medulla (nucleus paragigantocellularis) to the locus coeruleus in rat
- Creators
- Bernadette Astier - Université Claude Bernard Lyon 1Elisabeth J. Van Bockstaele - New York UniversityGary Aston-Jones - Department of Mental Health Sciences, Hahnemann University, Philadelphia, PA 19102-1192 U.S.AVincent A. Pieribone - Karolinska Institutet
- Publication Details
- Neuroscience letters, v 118(2), pp 141-146
- Publisher
- Elsevier Ireland Ltd; CLARE
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1990EF83900001
- Scopus ID
- 2-s2.0-0025076980
- Other Identifier
- 991021903287104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences