Journal article
Anesthesia Inhibits Interferon-Induced Natural Killer Cell Cytotoxicity via Induction of CD8 + Suppressor Cells
Cellular immunology, v 151(2), pp 474-480
15 Oct 1993
PMID: 8402951
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Anesthesia (Avertin, halothane, isoflorane, ether, or ketamine/xylazan) of mice inhibits subsequent stimulation of splenic natural killer cell (NK) cytotoxicity by interferon (IFN) treatment either
in vitro and
in vivo. The current data demonstrate (a)
in vitro depletion of CD8
+ cells from mononuclear splenocytes of anesthetized mice restored the ability of NK cells to respond
in vitro to IFN stimulation and (b) coincubation of CD8
+ splenocytes from anesthetized mice with CD8
- splenocytes of naive mice resulted in a significant reduction of the IFN-induced stimulation of NK activity in the coculture. These results suggest that anesthesia induces CD8+ cells that suppress stimulation of NK cytotoxicity by IFN.
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Details
- Title
- Anesthesia Inhibits Interferon-Induced Natural Killer Cell Cytotoxicity via Induction of CD8 + Suppressor Cells
- Creators
- Svetomir N. Markovic - Drexel UniversityDonna M. Murasko - Drexel University
- Publication Details
- Cellular immunology, v 151(2), pp 474-480
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:A1993MC13600022
- Scopus ID
- 2-s2.0-0027423301
- Other Identifier
- 991020950771604721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Immunology