Journal article
Angiocentric CD3 + T-Cell Infiltrates in Human Immunodeficiency Virus Type 1-Associated Central Nervous System Disease in Children
Clinical and diagnostic laboratory immunology, v 6(1)
Jan 1999
PMID: 9874673
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
ABSTRACT
A significant proportion of brain tissue specimens from children with AIDS show evidence of vascular inflammation in the form of transmural and/or perivascular mononuclear-cell infiltrates at autopsy. Previous studies have shown that in contrast to inflammatory lesions observed in human immunodeficiency virus type 1 (HIV-1) encephalitis, in which monocytes/macrophages are the prevailing mononuclear cells, these infiltrates consist mostly of lymphocytes. Perivascular mononuclear-cell infiltrates were found in brain tissue specimens collected at autopsy from five of six children with AIDS and consisted of CD3
+
T cells and equal or greater proportions of CD68
+
monocytes/macrophages. Transmural (including endothelial) mononuclear-cell infiltrates were evident in one patient and comprised predominantly CD3
+
T cells and small or, in certain vessels, approximately equal proportions of CD68
+
monocytes/macrophages. There was a clear preponderance of CD3
+
CD8
+
T cells on the endothelial side of transmural infiltrates. In active lesions of transmural vasculitis, CD3
+
T-cell infiltrates exhibited a distinctive zonal distribution. The majority of CD3
+
cells were also CD8
+
and CD45RO
+
. Scattered perivascular monocytes/macrophages in foci of florid vasculitis were immunoreactive for the p24 core protein. In contrast to the perivascular space, the intervening brain neuropil was dominated by monocytes/macrophages, microglia, and reactive astrocytes, containing only scant CD3
+
CD8
+
cells. Five of six patients showed evidence of calcific vasculopathy, but only two exhibited HIV-1 encephalitis. One patient had multiple subacute cerebral and brainstem infarcts associated with a widespread, fulminant mononuclear-cell vasculitis. A second patient had an old brain infarct associated with fibrointimal thickening of large leptomeningeal vessels. These infiltrating CD3
+
T cells may be responsible for HIV-1-associated CNS vasculitis and vasculopathy and for endothelial-cell injury and the opening of the blood-brain barrier in children with AIDS.
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Details
- Title
- Angiocentric CD3 + T-Cell Infiltrates in Human Immunodeficiency Virus Type 1-Associated Central Nervous System Disease in Children
- Creators
- Christos D. Katsetos - Department of Microbiology and Immunology1 andJohn E. Fincke - Department of Microbiology and Immunology1 andAgustin Legido - Temple UniversityHarold W. Lischner - Immunology,3Jean-Pierre de Chadarevian - St. Christopher's Hospital for ChildrenEdward M. Kaye - Temple UniversityChris D. Platsoucas - Department of Microbiology and Immunology1 andEmilia L. Oleszak - Fels Institute for Cancer Research and Molecular Biology and Departments of Biochemistry and Neurology,5
- Publication Details
- Clinical and diagnostic laboratory immunology, v 6(1)
- Publisher
- American Society for Microbiology (ASM)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000077980900019
- Scopus ID
- 2-s2.0-0032958389
- Other Identifier
- 991019347015104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology