Journal article
Angiocidin promotes pro-inflammatory cytokine production and antigen presentation in multiple sclerosis
Journal of neuroimmunology, v 194(1-2), pp 132-142
01 Feb 2008
PMID: 18207252
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Angiocidin was originally identified as a potent inhibitor of angiogenesis and tumor growth in vivo. In addition to its involvement in the regulation of carcinogenesis, recent studies indicate that angiocidin may also play a significant role in immune system modulation. This report describes the expression and potential function of angiocidin in multiple sclerosis (MS), a severe demyelinating, inflammatory and autoimmune disease of the central nervous system (CNS). We demonstrated that angiocidin and interleukin-7 (IL-7) are over-expressed in brain lesions of MS patients. Angiocidin-treated monocytes, peripheral blood T cells and primary astrocytes secreted various cytokines and chemokines including, IL-6, IL-7, GM-CSF, and MCP-1. Addition of recombinant angiocidin to cell cultures was able to promote differentiation of monocytes into a macrophage-like cell, induce MHC class I and class II. gene expression and activate CD4(+) and CD8(+) T lymphocytes. Consistent with these findings, angiocidin induced mononuclear phagocyte migration and adhesion as well as increased the IL-2 response by antigen-specific T cells to myelin basic protein peptide presented to them by autologous mononuclear phagocytes. Furthermore, we examined STAT3 expression in angiocidin stimulated mononuclear phagocytes, T cells, and primary astrocytes. We found that angiocidin markedly stimulates STAT3 expression in these cell populations. Angiocidin, therefore appears to play a previously unappreciated and potentially important role in the regulation of immune response during the clinical course of MS. (C) 2007 Elsevier B.V. All rights reserved.
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Details
- Title
- Angiocidin promotes pro-inflammatory cytokine production and antigen presentation in multiple sclerosis
- Creators
- Sergey G. Kremlev - Temple UniversityAnita L. Gaurnier-Hausser - Temple UniversityLuis Del Valle - Temple UniversityGeorgina Perez-Liz - Temple UniversitySvetoslav Dimitrov - Temple UniversityGeorge Tuszynski - Temple University
- Publication Details
- Journal of neuroimmunology, v 194(1-2), pp 132-142
- Publisher
- Elsevier
- Number of pages
- 11
- Grant note
- R01CA088931 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01 CA88931 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute; Intensive Medical Sciences (IMS)
- Web of Science ID
- WOS:000254683600018
- Scopus ID
- 2-s2.0-39849102619
- Other Identifier
- 991021930425604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Neurosciences