Journal article
Angiogenic Self-Assembling Peptide Scaffolds for Functional Tissue Regeneration
Biomacromolecules, Vol.19(9), pp.3597-3611
10 Sep 2018
PMID: 30132656
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Implantation of acellular biomimetic scaffolds with proangiogenic motifs may have exciting clinical utility for the treatment of ischemic pathologies such as myocardial infarction. Although direct delivery of angiogenic proteins is a possible treatment option, smaller synthetic peptide-based nanostructured alternatives are being investigated due to favorable factors, such as sustained efficacy and high-density epitope presentation of functional moieties. These peptides may be implanted in vivo at the site of ischemia, bypassing the first-pass metabolism and enabling long-term retention and sustained efficacy. Mimics of angiogenic proteins show tremendous potential for clinical use. We discuss possible approaches to integrate the functionality of such angiogenic peptide mimics into self-assembled peptide scaffolds for application in functional tissue regeneration.
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Details
- Title
- Angiogenic Self-Assembling Peptide Scaffolds for Functional Tissue Regeneration
- Creators
- Biplab Sarkar - New Jersey Institute of TechnologyPeter K. Nguyen - New Jersey Institute of TechnologyWilliam Gao - New Jersey Institute of TechnologyAkhil Dondapati - New Jersey Institute of TechnologyZain Siddiqui - New Jersey Institute of TechnologyVivek A. Kumar - Rutgers, The State University of New Jersey
- Publication Details
- Biomacromolecules, Vol.19(9), pp.3597-3611
- Publisher
- Amer Chemical Soc
- Number of pages
- 15
- Grant note
- NJIT NSF iCorps program
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Identifiers
- 991021956615104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Organic
- Polymer Science