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Journal article
Anharmonic transitions in nearly dry L-cysteine I
Journal of physics. Condensed matter, v 24(19), pp 195104-195104
16 May 2012
PMID: 22499214
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Abstract
Two special dynamical transitions of universal character have recently been observed in macromolecules (lysozyme, myoglobin, bacteriorhodopsin, DNA and RNA) at T* similar to 100-150 K and T-D similar to 180-220 K. The underlying mechanisms governing these transitions have been the subject of debate. In the present work, a survey is reported on the temperature dependence of structural, vibrational and thermodynamical properties of a nearly anhydrous amino acid (orthorhombic polymorph of the amino acid L-cysteine at a hydration level of 3.5%). The temperature dependence of x-ray powder diffraction patterns, Raman spectra and specific heat revealed these two transitions at T* = 70 K and T-D = 230 K for this sample. The data were analyzed considering amino acid-amino acid, amino acid-water, water-water phonon-phonon interactions and molecular rotor activation. Our results indicated that the two referred temperatures define the triggering of very simple and particular events that govern all the interactions of the biomolecular: activation of CH2 rigid rotors (T < T*), phonon-phonon interactions between specific amino acid and water dimer vibrational modes (T* < T < T-D), and water rotational barriers surpassing (T > T-D).
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Details
- Title
- Anharmonic transitions in nearly dry L-cysteine I
- Creators
- T. A. Lima - Universidade Federal do ABCE. T. Sato - Universidade Federal do ABCE. T. Martins - Universidade Federal do ABCP. Homem-de-Mello - Universidade Federal do ABCA. F. Lago - Universidade Federal do ABCM. D. Coutinho-Neto - Universidade Federal do ABCF. F. Ferreira - Universidade Federal do ABCC. Giles - State University of CampinasM. O. C. Pires - Universidade Federal do ABCH. Martinho - UFABC, Ctr Ciencias Nat & Humanas, BR-09210170 Sao Paulo, Brazil
- Publication Details
- Journal of physics. Condensed matter, v 24(19), pp 195104-195104
- Publisher
- Iop Publishing Ltd
- Number of pages
- 9
- Grant note
- 301018/2006-5 / CNPq; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) 2011/06618-0 / FAPESP; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000303501000006
- Scopus ID
- 2-s2.0-84860119364
- Other Identifier
- 991019299111604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Physics, Condensed Matter