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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Animal farming and the risk of lymphohaematopoietic cancers: a meta-analysis of three cohort studies within the AGRICOH consortium
Occupational and environmental medicine (London, England), v 76(11), pp 827-837
01 Nov 2019
PMID: 31302607
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective Animal farming entails a variety of potential exposures, including infectious agents, endotoxins and pesticides, which may play a role in the aetiology of lymphohaematopoietic cancers (LHCs). The aim of this study was to assess whether farming specific animal species is associated with the risk of overall LHC or its subtypes. Methods Data from three prospective cohort studies in the USA, France and Norway which are part of the Agricultural Cohort consortium and which collected information about animal farming and cancer were used. Analyses included 316 270 farmers and farm workers. Adjusted Cox models were used to investigate the associations of 13 histological subtypes of LHC (n=3282) with self-reported livestock (cattle, pigs and sheep/goats) and poultry (ever/never and numbers raised) farming. Cohort-specific HRs were combined using random-effects meta-analysis. Results Ever animal farming in general or farming specific animal species was not meta-associated with overall LHC. The risk of myeloid malignancies decreased with increasing number of livestock (p trend=0.01). Increased risk of myeloproliferative neoplasms was seen with increasing number of sheep/goats (p trend <0.01), while a decreased risk was seen with increasing number of livestock (p trend=0.02). Between cohorts, we observed heterogeneity in the association of type of animal farmed and various LHC subtypes. Conclusions This large-scale study of three prospective agricultural cohorts showed no association between animal farming and LHC risk, but few associations between specific animal species and LHC subtypes were observed. The observed differences in associations by countries warrant further investigations.
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- Title
- Animal farming and the risk of lymphohaematopoietic cancers: a meta-analysis of three cohort studies within the AGRICOH consortium
- Creators
- Sonia El-Zaemey - School of Public HealthLeah H. Schinasi - Section of Environment and RadiationGilles Ferro - International Agency For Research On CancerSeverine Tual - Université de Caen NormandiePierre Lebailly - Université de Caen NormandieIsabelle Baldi - Conseil Interprofessionnel du Vin de BordeauxKarl-Christian Nordby - National Institute of Occupational HealthKristina Kjaerheim - Canc Registry Norway, Dept Res, Oslo, NorwayJoachim Schuz - International Agency For Research On CancerAlain Monnereau - Hematological Malignancies Registry of GirondeMaartje Brouwer - Utrecht UniversityStella Koutros - National Cancer InstituteJonathan Hofmann - National Cancer InstitutePetter Kristensen - National Institute of Occupational HealthHans Kromhout - Utrecht UniversityMaria E. Leon - International Agency For Research On CancerLaura E. Beane Freeman - NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
- Publication Details
- Occupational and environmental medicine (London, England), v 76(11), pp 827-837
- Publisher
- Bmj Publishing Group
- Number of pages
- 11
- Grant note
- Z01-CP010119 / Intramural Research Program of the National Cancer Institute, National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) VGP.14/20 / Ammodo van Gogh travel grant Cancer Council Australia (CCA); Cancer Council Australia Office National de l'Eau et des Milieux Aquatiques (ONEMA), Plan d'action national ECOPHYTO 2018, Axe 3, Volet 4, France
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000497712200007
- Scopus ID
- 2-s2.0-85069456477
- Other Identifier
- 991019169152604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health