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Animal models of systemic sclerosis: their utility and limitations
Journal article   Open access   Peer reviewed

Animal models of systemic sclerosis: their utility and limitations

Carol M Artlett
Open access rheumatology: research and reviews, v 6, pp 65-81
01 Jul 2014
PMID: 27790036
url
https://doi.org/10.2147/oarrr.s50009View
Published, Version of Record (VoR)CC BY-NC V4.0 Open
url
https://doi.org/10.2147/OARRR.S50009View
Published, Version of Record (VoR) Open

Abstract

animal models chicken fibrosis mouse Review systemic sclerosis vasculopathy
Without doubt, animal models have provided significant insights into our understanding of the rheumatological diseases; however, no model has accurately replicated all aspects of any autoimmune disease. Recent years have seen a plethora of knockouts and transgenics that have contributed to our knowledge of the initiating events of systemic sclerosis, an autoimmune disease. In this review, the focus is on models of systemic sclerosis and how they have progressed our understanding of fibrosis and vasculopathy, and whether they are relevant to the pathogenesis of systemic sclerosis.

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Web of Science research areas
Rheumatology
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