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Journal article
Annealing post-drawn polycaprolactone (PCL) nanofibers optimizes crystallinity and molecular alignment and enhances mechanical properties and drug release profiles
Materials advances, v 3(7), pp 333-3315
09 Mar 2022
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Abstract
Post-drawn PCL nanofibers can be molecularly tuned to have a variety of mechanical properties and drug release profiles depending on the temperature and time of annealing, which has implications for regenerative medicine and drug delivery applications. Post-drawing polycaprolactone (PCL) nanofibers has previously been demonstrated to drastically increase their mechanical properties. Here the effects of annealing on post-drawn PCL nanofibers are characterized. It is shown that room temperature storage and in vivo temperatures increase crystallinity significantly on the order of weeks, and that high temperature annealing near melt significantly increases crystallinity and molecular orientation on the order of minutes. The kinetics of crystallization were assessed using an anneal and quench approach. High temperature annealing also increased the ultimate tensile strength and toughness of the fibers and changed the release profile of a model drug absorbed in PCL nanofibers from first-order to zero-order kinetics.
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Details
- Title
- Annealing post-drawn polycaprolactone (PCL) nanofibers optimizes crystallinity and molecular alignment and enhances mechanical properties and drug release profiles
- Creators
- Matthew D. Flamini - Rowan UniversityThamires Lima - Drexel UniversityKerri Corkum - Rowan UniversityNicolas J. Alvarez - Drexel UniversityVince Beachley - Rowan University
- Publication Details
- Materials advances, v 3(7), pp 333-3315
- Publisher
- Royal Soc Chemistry
- Number of pages
- 13
- Grant note
- NSF1653329 / National Science Foundation; National Science Foundation (NSF) W911NF-17-2-0227 / Army Research Laboratory; United States Department of Defense; US Army Research Laboratory (ARL)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000766256500001
- Scopus ID
- 2-s2.0-85127012179
- Other Identifier
- 991019167689304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Materials Science, Multidisciplinary