Journal article
Annexin A2 (ANX A2): An emerging biomarker and potential therapeutic target for aggressive cancers
International journal of cancer, v 144(9), pp 2074-2081
01 May 2019
PMID: 30125343
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
ANX A2 is an important member of annexin family of proteins expressed on surface of endothelial cells (ECs), macrophages, mononuclear cells and various types of cancer cells. It exhibits high affinity binding for calcium (Ca++) and phospholipids. ANX A2 plays an important role in many biological processes such as endocytosis, exocytosis, autophagy, cell-cell communications and biochemical activation of plasminogen. On the cell surface ANX A2 organizes the assembly of plasminogen (PLG) and tissue plasminogen activator (tPA) for efficient conversion of PLG to plasmin, a serine protease. Proteolytic activity of plasmin is required for activation of inactive pro-metalloproteases (pro-MMPs) and latent growth factors for their biological actions. These activation steps are critical for degradation of extracellular matrix (ECM) and basement proteins (BM) for cancer cell invasion and metastasis. Increased expression of ANX A2 protein/gene has been correlated with invasion and metastasis in a variety of human cancers. Moreover, clinical studies have positively correlated ANX A2 protein expression with aggressive cancers and with resistance to anticancer drugs, shorter disease-free survival (DFS), and worse overall survival (OS). The mechanism(s) by which ANX A2 regulates cancer invasion and metastasis are beginning to emerge. Investigators used various technologies to target ANX A2 in preclinical model of human cancers and demonstrated exciting results. In this review article, we analyzed existing literature concurrent with our own findings and provided a critical overview of ANX A2-dependent mechanism(s) of cancer invasion and metastasis.
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Details
- Title
- Annexin A2 (ANX A2): An emerging biomarker and potential therapeutic target for aggressive cancers
- Creators
- Mahesh C. Sharma - George Washington University
- Publication Details
- International journal of cancer, v 144(9), pp 2074-2081
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- Research Services of the Veterans Affairs Medical Center, Washington, DC Research Services of the Veterans Affairs Medical Center, Washington DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000460343700003
- Scopus ID
- 2-s2.0-85055868476
- Other Identifier
- 991019187068604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology