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Published, Version of Record (VoR)Open Access via Drexel Libraries Read and Publish Program 2024CC BY V4.0, Open
Journal article
Antagonistic roles of tau and MAP6 in regulating neuronal development
Journal of Cell Science , v 137(19), 261966
07 Oct 2024
PMID: 39257379
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Association of tau with microtubules causes them to be labile while association of MAP6 with microtubules causes them to be stable. As axons differentiate and grow, tau and MAP6 segregate from one another on individual microtubules, resulting in the formation of stable and labile domains. The functional significance of the yin/yang relationship between tau and MAP6 remains speculative, with one idea being that such a relationship assists in balancing morphological stability with plasticity. Here, using primary rodent neuronal cultures, we show that tau depletion has opposite effects compared to MAP6 depletion on the rate of neuronal development, the efficiency of growth cone turning, and the number of neuronal processes and axonal branches. Opposite effects to those of tau depletion were also observed on the rate of neuronal migration, in an in vivo assay, when MAP6 was depleted. When tau and MAP6 were together depleted from neuronal cultures, the morphological phenotypes negated one another. Although tau and MAP6 are multifunctional proteins, our results suggest that the observed effects on neuronal development are likely due to their opposite roles in regulating microtubule stability.
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Details
- Title
- Antagonistic roles of tau and MAP6 in regulating neuronal development
- Creators
- Liang Qiang (Corresponding Author) - Drexel University, Neurobiology and AnatomyXiaohuan Sun - Drexel UniversityWenqian Yu - Drexel University, Neurobiology and AnatomyPeter W Baas - Drexel University, Neurobiology and AnatomyKazuhito Toyooka - Drexel University, Neurobiology and Anatomy
- Publication Details
- Journal of Cell Science , v 137(19), 261966
- Publisher
- Company of Biologists
- Number of pages
- 7
- Grant note
- Lisa Dean Moseley Foundation National Institutes of Health (National Institute of Neurological Disorders and Stroke): R01NS115977, R01NS096098-01A1, R01NS28785 CURE program from Drexel University College of Medicine: 4100085747, SAP: 4100083087 National Institutes of Health (National Institute on Aging): R21AG068597 USA Department of Defense: W81XWH2110189 Drexel University
This study was supported by grants from the Lisa Dean Moseley Foundation (L.Q.) , National Institutes of Health (National Institute of Neurological Disorders and Stroke) [R01NS115977 (L.Q.) , R01NS096098-01A1 (K.T.) , R01NS28785 (P.W.B.) ] , the CURE program from Drexel University College of Medicine [SAP: 4100083087 (L.Q.) , 4100085747 (K.T.)] , National Institutes of Health (National Institute on Aging) [R21AG068597 (P.W.B.) ] , and the USA Department of Defense [W81XWH2110189 (P.W.B.)] . Open access funding provided by Drexel University. Deposited in PMC for immediate release.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; Pharmacology and Physiology
- Web of Science ID
- WOS:001341177900013
- Scopus ID
- 2-s2.0-85207052762
- Other Identifier
- 991021902715404721
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- Web of Science research areas
- Cell Biology