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Antenatal Events Causing Neonatal Brain Injury in Premature Infants
Journal article   Peer reviewed

Antenatal Events Causing Neonatal Brain Injury in Premature Infants

Joan Rosen Bloch
Journal of obstetric, gynecologic, and neonatal nursing, v 34(3), pp 358-366
May 2005
PMID: 15890835

Abstract

Antenatal brain insults Chronic illness effects on fetus Fetal developmental pathophysiology Fetal effects of maternal smoking, infection, and alcohol consumption Germinal matrix/intraventricular hemorrhage (GM/IVH) Low birth weight Neonatal brain injury Periventricular leukomalacia (PVL) Premature infants Prenatal care
Understanding possible causes of neonatal brain injury is important for perinatal nurses because neonatal brain injury predicts subsequent infant mortality and morbidity in the premature infant. The pathogenesis of the brain injury, germinal matrix/intraventricular hemorrhage and white matter damage, is usually related to a hypoxic event. The hypoxic event may occur in utero, resulting from various conditions, such as maternal infection, maternal alcohol consumption, maternal smoking, placental bleeding disorders, maternal hypercoagulability conditions, metabolic disorders (diabetes and hyperthyroidism), and oligohydramnios. Strategies for prevention beginning before and in pregnancy are needed.

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Web of Science research areas
Nursing
Obstetrics & Gynecology
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