Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Antenatal Magnesium and Cerebral Palsy in Preterm Infants
The Journal of pediatrics, v 167(4), pp 834-839.e3
Oct 2015
PMID: 26254839
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To evaluate the relationship of maternal antenatal magnesium sulfate (MgSO4) with neonatal cranial ultrasound abnormalities and cerebral palsy (CP).
In a randomized trial of MgSO4 or placebo in women at high risk of preterm delivery, up to 3 cranial ultrasounds were obtained in the neonatal period. Images were reviewed by at least 2 pediatric radiologists masked to treatment and other clinical conditions. Diagnoses were predefined for intraventricular hemorrhage, periventricular leukomalacia, intracerebral echolucency or echodensity, and ventriculomegaly. CP was diagnosed at 2 years of age by standardized neurologic examination.
Intraventricular hemorrhage, periventricular leukomalacia, intracerebral echolucency or echodensity, and ventriculomegaly were all strongly associated with an increased risk of CP. MgSO4 administration did not affect the risk of cranial ultrasound abnormality observed at 35 weeks postmenstrual age or later. However, for the 82% of infants born at <32 weeks gestation, MgSO4 was associated with a reduction in risk of echolucency or echodensity. The reduction in risk for echolucency explained 21% of the effect of MgSO4 on CP (P = .04), and for echodensity explained 20% of the effect (P = .02).
MgSO4 given prior to preterm delivery was associated with decreased risk of developing echodensities and echolucencies at <32 weeks gestation. However, this effect can only partially explain the effect of MgSO4 on CP at 2 years of age.
ClinicalTrials.gov: NCT00014989.
Metrics
Details
- Title
- Antenatal Magnesium and Cerebral Palsy in Preterm Infants
- Creators
- Deborah G Hirtz - National Institutes of HealthSteven J Weiner - George Washington UniversityDorothy Bulas - Children’s National Health SystemMichael DiPietro - University of Michigan–Ann ArborJoanna Seibert - Arkansas Children's HospitalDwight J Rouse - University of Alabama at BirminghamBrian M Mercer - Department of Obstetrics and Gynecology, Case Western Reserve University-MetroHealth Medical Center, Cleveland, OH, and University of Tennessee, Memphis, TNMichael W Varner - University of UtahUma M Reddy - National Institutes of HealthJay D Iams - The Ohio State UniversityRonald J Wapner - Drexel UniversityYoram Sorokin - Wayne State UniversityJohn M Thorp, Jr - Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NCSusan M Ramin - The University of Texas Health Science Center at HoustonFergal D Malone - Columbia UniversityMarshall W Carpenter - Brown UniversityMary J O'Sullivan - University of MiamiAlan M Peaceman - Northwestern UniversityGary D V Hankins - The University of Texas Medical Branch at GalvestonDonald Dudley - The University of Texas at San AntonioSteve N Caritis - University of PittsburghEunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units NetworkThelicia Hill - Intensive Medical Sciences (IMS)
- Publication Details
- The Journal of pediatrics, v 167(4), pp 834-839.e3
- Publisher
- Elsevier
- Grant note
- HD40485 / NICHD NIH HHS U10 HD027860 / NICHD NIH HHS U10 HD027915 / NICHD NIH HHS HD34136 / NICHD NIH HHS U10 HD021410 / NICHD NIH HHS UG1 HD027915 / NICHD NIH HHS UG1 HD034116 / NICHD NIH HHS HD21414 / NICHD NIH HHS M01-RR-000080 / NCRR NIH HHS HD40545 / NICHD NIH HHS HD53907 / NICHD NIH HHS M01 RR000080 / NCRR NIH HHS U10 HD034116 / NICHD NIH HHS HD40544 / NICHD NIH HHS HD27861 / NICHD NIH HHS HD27917 / NICHD NIH HHS HD40560 / NICHD NIH HHS U10 HD034208 / NICHD NIH HHS UG1 HD040485 / NICHD NIH HHS U10 HD027917 / NICHD NIH HHS HD21410 / NICHD NIH HHS UG1 HD040560 / NICHD NIH HHS HD27915 / NICHD NIH HHS UG1 HD040544 / NICHD NIH HHS UG1 HD040512 / NICHD NIH HHS UG1 HD027869 / NICHD NIH HHS U10 HD027905 / NICHD NIH HHS U10 HD034136 / NICHD NIH HHS U10 HD034122 / NICHD NIH HHS HD34210 / NICHD NIH HHS HD27860 / NICHD NIH HHS UG1 HD040545 / NICHD NIH HHS U10 HD040500 / NICHD NIH HHS HD27869 / NICHD NIH HHS HD34208 / NICHD NIH HHS UG1 HD040500 / NICHD NIH HHS U10 HD036801 / NICHD NIH HHS U10 HD040545 / NICHD NIH HHS U10 HD040544 / NICHD NIH HHS U10 HD040512 / NICHD NIH HHS Z99 NS999999 / Intramural NIH HHS HD36801 / NICHD NIH HHS HD40512 / NICHD NIH HHS U10 HD027869 / NICHD NIH HHS HD34116 / NICHD NIH HHS U10 HD040560 / NICHD NIH HHS U01 HD019897 / NICHD NIH HHS UG1 HD034208 / NICHD NIH HHS UL1 TR000439 / NCATS NIH HHS U10 HD040485 / NICHD NIH HHS HD40500 / NICHD NIH HHS U01 HD036801 / NICHD NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Intensive Medical Sciences (IMS)
- Web of Science ID
- WOS:000363545800013
- Scopus ID
- 2-s2.0-84965188539
- Other Identifier
- 991019173554004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics