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Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Antenatal risk factors, cytokines and the development of atopic disease in early childhood
Archives of disease in childhood. Fetal and neonatal edition, v 92(1), pp F68-F73
Jan 2007
PMID: 17185433
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Atopic diseases are complex entities influenced by an array of risk factors, including genetic predisposition, environmental allergens, antenatal exposures, infections and psychosocial factors. One proposed mechanism by which these risk factors contribute to the development of atopic disease is through changes in the production of T helper cell type 1 (Th1) and T helper cell type 2 (Th2) cytokines. The objectives of this review are to discuss antenatal exposures that are associated with paediatric atopic diseases, to discuss the influence of the intrauterine environment on neonatal immune responses, to provide an overview of the Th1 and Th2 pathways and how they relate to atopic disease, and to summarise our current understanding of the association between cytokine responses in cord blood and the development of atopic disease in early childhood.
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Details
- Title
- Antenatal risk factors, cytokines and the development of atopic disease in early childhood
- Creators
- E K Chung - Jefferson CollegeR L Miller - Columbia UniversityM T WilsonS J McGeadyJ F Culhane - Drexel University
- Publication Details
- Archives of disease in childhood. Fetal and neonatal edition, v 92(1), pp F68-F73
- Publisher
- BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000243394000023
- Scopus ID
- 2-s2.0-33846434104
- Other Identifier
- 991019339572904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics