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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Anthropometrically-predicted visceral adipose tissue and mortality among men and women in the third national health and nutrition examination survey (NHANES III)
American journal of human biology, v 29(1), pn/a
01 Jan 2017
PMID: 27427402
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
ObjectiveThis study seeks to quantify the relationship between anthropometrically-predicted visceral adipose tissue (apVAT) and all-cause and cause-specific mortality among individuals of European descent in a population-based prospective cohort study of 10,624 participants.
MethodsThe apVAT with a validated regression equation that included age, body mass index, and waist and thigh circumferences were predicted.
ResultsDuring a median of 18.8 years, 3531 participants died with 1153 and 741 deaths attributable to cardiovascular disease and cancer, respectively. In multivariable-adjusted analyses that accounted for demographic, clinical, and behavioral characteristics, higher apVAT was associated with an increased risk of all-cause (P-trend<.001), cardiovascular-specific (P-trend<.001), and cancer-specific mortality (P-trend=.007). Excluding participants with a history of cancer, myocardial infarction, heart failure, or diabetes at baseline did not substantively alter effect estimates. apVAT more accurately predicted all-cause, cardiovascular-specific, and cancer-specific mortality than body mass index (P<.001), waist circumference (P<.001), or the combination of body mass index and waist circumference (P<.001).
ConclusionsThese data provide evidence that apVAT is associated with all-cause and cause-specific mortality in a large population-based sample of men and women of European descent. These results support the use of apVAT to risk-stratify individuals for premature mortality when imaging data are not available such as in routine clinical practice or in large clinical trials.
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Details
- Title
- Anthropometrically-predicted visceral adipose tissue and mortality among men and women in the third national health and nutrition examination survey (NHANES III)
- Creators
- Justin C. Brown - University of PennsylvaniaMichael O. Harhay - University of PennsylvaniaMeera N. Harhay - Drexel University
- Publication Details
- American journal of human biology, v 29(1), pn/a
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- K23DK105207 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) F31-CA192560; R21-CA182726 / National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R21CA182767 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) K23-DK105207 / National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) F31HL127947 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) F31-HL127947 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000393614900008
- Scopus ID
- 2-s2.0-84992035155
- Other Identifier
- 991019335235904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Anthropology
- Biology