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Journal article
Anti-HIV antibody development up to 1 year after antiretroviral therapy initiation in acute HIV infection
The Journal of clinical investigation, v 132(1)
04 Jan 2022
PMID: 34762600
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Early initiation of antiretroviral therapy (ART) in acute HIV infection (AHI) is effective at limiting seeding of the HIV viral reservoir, but little is known about how the resultant decreased antigen load affects long-term Ab development after ART. We report here that Env-specific plasma antibody (Ab) levels and Ab-dependent cellular cytotoxicity (ADCC) increased during the first 24 weeks of ART and correlated with Ab levels persisting after 48 weeks of ART. Participants treated in AHI stage 1 had lower Env-specific Ab levels and ADCC activity on ART than did those treated later. Importantly, participants who initiated ART after peak viremia in AHI developed elevated cross-clade ADCC responses that were detectable 1 year after ART initiation, even though clinically undetectable viremia was reached by 24 weeks. These data suggest that there is more germinal center (GC) activity in the later stages of AHI and that Ab development continues in the absence of detectable viremia during the first year of suppressive ART. The development of therapeutic interventions that can enhance earlier development of GCs in AHI and Abs after ART initiation could provide important protection against the viral reservoir that is seeded in individuals treated early in the disease.
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Details
- Title
- Anti-HIV antibody development up to 1 year after antiretroviral therapy initiation in acute HIV infection
- Creators
- Julie L Mitchell - Henry M. Jackson FoundationJustin Pollara - Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.Kenneth Dietze - Henry M. Jackson FoundationR Whitney Edwards - Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.Junsuke Nohara - Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.Kombo F N'guessan - Henry M. Jackson FoundationMichelle Zemil - Henry M. Jackson FoundationSupranee Buranapraditkun - Chulalongkorn UniversityHiroshi Takata - Henry M. Jackson FoundationYifan Li - Henry M. Jackson FoundationRoshell Muir - Drexel UniversityEugene Kroon - Institute of Research and InnovationSuteeraporn Pinyakorn - Henry M. Jackson FoundationShalini Jha - Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.Sopark Manasnayakorn - Department of Medicine and.Suthat Chottanapund - Bamrasnaradura Infectious Diseases InstitutePattarawat Thantiworasit - Chulalongkorn UniversityPeeriya Prueksakaew - Institute of Research and InnovationNisakorn Ratnaratorn - Institute of Research and InnovationBessara Nuntapinit - Armed Forces Research Institute of Medical ScienceLawrence Fox - National Institute of Allergy and Infectious DiseasesSodsai Tovanabutra - Henry M. Jackson FoundationDominic Paquin-Proulx - Henry M. Jackson FoundationLindsay Wieczorek - Henry M. Jackson FoundationVictoria R Polonis - Henry M. Jackson FoundationFrank Maldarelli - National Cancer InstituteElias K Haddad - Drexel UniversityPraphan Phanuphak - Institute of Research and InnovationCarlo P Sacdalan - Institute of Research and InnovationMorgane Rolland - Henry M. Jackson FoundationNittaya Phanuphak - Institute of Research and InnovationJintanat Ananworanich - University of AmsterdamSandhya Vasan - Henry M. Jackson FoundationGuido Ferrari - Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.Lydie Trautmann - Henry M. Jackson FoundationRV254 and RV304 Study Groups
- Publication Details
- The Journal of clinical investigation, v 132(1)
- Publisher
- American Society for Clinical Investigation
- Grant note
- R01 AI108433 / NIAID NIH HHS AAI20052001 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000747074000012
- Scopus ID
- 2-s2.0-85122779591
- Other Identifier
- 991019167942904721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Medicine, Research & Experimental