Journal article
Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus
Lupus science & medicine, v 11(1), 001139
09 Apr 2024
PMID: 38599670
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background Cranial neuropathies (CN) are a rare neuropsychiatric SLE (NPSLE) manifestation. Previous studies reported that antibodies to the kinesin family member 20B (KIF20B) (anti-KIF20B) protein were associated with idiopathic ataxia and CN. We assessed anti-KIF20B as a potential biomarker for NPSLE in an international SLE inception cohort.Methods Individuals fulfilling the revised 1997 American College of Rheumatology (ACR) SLE classification criteria were enrolled from 31 centres from 1999 to 2011 and followed annually in the Systemic Lupus Erythematosus International Collaborating Clinics inception cohort. Anti-KIF20B testing was performed on baseline (within 15 months of diagnosis or first annual visit) samples using an addressable laser bead immunoassay. Logistic regression (penalised maximum likelihood and adjusting for confounding variables) examined the association between anti-KIF20B and NPSLE manifestations (1999 ACR case definitions), including CN, occurring over the first 5 years of follow-up.Results Of the 1827 enrolled cohort members, baseline serum and 5 years of follow-up data were available on 795 patients who were included in this study: 29.8% were anti-KIF20B-positive, 88.7% female, and 52.1% White. The frequency of anti-KIF20B positivity differed only for those with CN (n=10) versus without CN (n=785) (70.0% vs 29.3%; OR 5.2, 95% CI 1.4, 18.5). Compared with patients without CN, patients with CN were more likely to fulfil the ACR haematological (90.0% vs 66.1%; difference 23.9%, 95% CI 5.0%, 42.8%) and ANA (100% vs 95.7%; difference 4.3%, 95% CI 2.9%, 5.8%) criteria. In the multivariate analysis adjusting for age at baseline, female, White race and ethnicity, and ACR haematological and ANA criteria, anti-KIF20B positivity remained associated with CN (OR 5.2, 95% CI 1.4, 19.1).Conclusion Anti-KIF20B is a potential biomarker for SLE-related CN. Further studies are needed to examine how autoantibodies against KIF20B, which is variably expressed in a variety of neurological cells, contribute to disease pathogenesis.
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Details
- Title
- Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus
- Creators
- Eugene Krustev - University of CalgaryJohn G. Hanly - Queen Elizabeth II Health Sciences CentreRicky Chin - University of CalgaryKatherine A. Buhler - University of CalgaryMurray B. Urowitz - University of TorontoCaroline Gordon - University of BirminghamSang-Cheol Bae - Hanyang UniversityJuanita Romero-Diaz - Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránJorge Sanchez-Guerrero - Mount Sinai HospitalSasha Bernatsky - McGill University Health CentreDaniel J. Wallace - Cedars-Sinai Medical CenterDavid Isenberg - University College LondonAnisur Rahman - University College LondonJoan T. Merrill - Oklahoma Medical Research FoundationPaul R. Fortin - Université LavalDafna D. Gladman - Toronto Western HospitalIan N. Bruce - Manchester Academic Health Science CentreMichelle A. Petri - Johns Hopkins MedicineEllen M. Ginzler - SUNY Downstate Health Sciences UniversityMary Anne Dooley - University of North Carolina at Chapel HillRosalind Ramsey-Goldman - Northwestern UniversitySusan Manzi - Allegheny Health NetworkAndreas Joensen - Lund UniversityGraciela S. Alarcon - University of Alabama at BirminghamRonald F. van Vollenhoven - University of AmsterdamCynthia Aranow - Feinstein Institute for Medical ResearchMeggan Mackay - Feinstein Institute for Medical ResearchGuillermo Ruiz-Irastorza - BioCruces Health research InstituteSam Lim - Emory UniversityMurat Inanc - Istanbul UniversityKenneth C. Kalunian - University of California, San DiegoSoren Jacobsen - Copenhagen Univ Hosp, Dept Rheumatol, Rigshosp, Copenhagen, DenmarkChristine A. Peschken - University of ManitobaDiane L. Kamen - Medical University of South CarolinaAnca Askenase - Columbia University Irving Medical CenterJill Buyon - NYU Langone Hlth, Rheumatol, New York, NY USAMarvin J. Fritzler - University of CalgaryAnn E. Clarke - University of CalgaryMay Y. Choi - University of Calgary
- Publication Details
- Lupus science & medicine, v 11(1), 001139
- Publisher
- Bmj Publishing Group
- Number of pages
- 9
- Grant note
- AR043727; AR069572; RR00046; 1U54TR001353; 8UL1TR000150; UL- 1RR- 025741; K24- AR- 02318; P60AR064464; P60- AR- 48098 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA NRF- 2021R1A6A1A03038899 / Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education; National Research Foundation of Korea; Ministry of Education (MOE), Republic of Korea; National Research Council for Economics, Humanities & Social Sciences, Republic of Korea Singer Family Fund for Lupus Research National Institute for Health Research University College London Hospitals Biomedical Research Centre NIHR203308 / NIHR Manchester Biomedical Research Centre; National Institutes of Health Research (NIHR) A1028 / Danish Rheumatism Association Lupus Foundation of America Gary S Gilkeson Career Development Award NIHR/Wellcome Trust Clinical Research Facility in Birmingham; Wellcome Trust Lupus UK, Sandwell and West Birmingham Hospitals NHS Trust MOP- 88526 / Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:001201871300006
- Scopus ID
- 2-s2.0-85190155898
- Other Identifier
- 991021934014804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology