Journal article
Anti-TNF Antibody Therapy for Inflammatory Bowel Disease During Pregnancy: A Clinical Review
Current drug targets, Vol.11(2), pp.234-241
01 Feb 2010
PMID: 19916950
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The incidence of inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis) is highest during the peak reproductive years, hence the increased concern with the safety of IBD drugs during pregnancy. Over the past 11 years, anti-TNF-alpha antibody therapy has emerged as a treatment approach for refractory IBD patients who have failed to achieve or maintain remission with corticosteroids and immunomodulator agents. The TNF-alpha inhibitors (anti-TNFs; infliximab, adalimumab, certolizumab pegol) have proven successful in inducing and maintaining remission of moderate-to-severe IBD, but recommendations for the use of these compounds during pregnancy have lacked consensus. Balanced against the potential risk of these drugs on the fetus is the well-established fact that high disease activity has been found to poorly affect pregnancy outcomes in IBD, and the potential use of anti-TNF agents may control disease flare and severity during pregnancy. Concerns regarding the effect of anti-TNFs on the pregnancy and fetus have been assuaged by registry data which has demonstrated an overall positive safety record. Both the U.S. Food and Drug Administration and the European Crohn's and Colitis Organization categorize anti-TNF agents as safe during pregnancy. New knowledge regarding the physiologic timing of placental transfer of therapeutic antibody subclasses and pegylated antibody fragments from the mother into the fetus has also helped to allay concerns. This review will examine the present state of knowledge regarding the use of anti-TNFs in pregnant women with IBD.
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Details
- Title
- Anti-TNF Antibody Therapy for Inflammatory Bowel Disease During Pregnancy: A Clinical Review
- Creators
- Marwa El Mourabet - UPMC PresbyterianSandra El-Hachem - University of PittsburghJanet R. Harrison - University of PittsburghDavid G. Binion - University of Pittsburgh
- Publication Details
- Current drug targets, Vol.11(2), pp.234-241
- Publisher
- Bentham Science Publ Ltd
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000274022500013
- Scopus ID
- 2-s2.0-77950832744
- Other Identifier
- 991022054321204721
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- Pharmacology & Pharmacy