Journal article
Anti-VEGF effects of intravitreal erythropoietin in early diabetic retinopathy
Frontiers in bioscience (Elite edition), v 2(3), pp 912-927
01 Jun 2010
PMID: 20515763
Abstract
In the present study, a single intravitreal erythropoietin (EPO) to diabetic rats produced therapeutic effects on blood-retinal barrier (BRB) function and neuronal survival at different time courses of retinopathy. In parallel, the hypoxia-inducible factor 1 alpha (HIF-1 alpha) pathway has been quantitatively studied, including VEGF-A, endogenous EPO, EPO receptor (EpoR), prolyl hydroxylases (PHD1-3) and von Hippel-Lindau tumor suppressor (VHL). The mRNA levels of HIF-1 alpha, VEGF-A, endogenous EPO, PHD1-3 and VHL are all up-regulated in the diabetic retina, and suppressed by exogenous EPO. The increased protein levels of HIF-1 alpha, VEGF-A, and endogenous EPO found in diabetic retinas also have been down-regulated by exogenous EPO. The results demonstrate that the HIF-1 pathway is activated in the retina in early diabetes, but is negatively regulated by a feedback loop following the administration of exogenous EPO. Exogenous EPO at pharmacologic levels leads to suppression of VEGF and in turn, restoration of the normal functions of BRB in a time-dependent manner. In the diabetic retina, the same level of exogenous EPO that inhibits VEGF also exerted neuronal protection.
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Details
- Title
- Anti-VEGF effects of intravitreal erythropoietin in early diabetic retinopathy
- Creators
- Jingfa Zhang - Tongji UniversityLiu-Mei HuGuoxu XuYalan WuJianfeng ShenYan LuoYong ZhongStephen H SinclairMyron YanoffWeiye LiGuo-Tong Xu
- Publication Details
- Frontiers in bioscience (Elite edition), v 2(3), pp 912-927
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Ophthalmology [Historical]
- Scopus ID
- 2-s2.0-77957334087
- Other Identifier
- 991019298716804721