Journal article
Antibacterial Activity of Ti₃C₂Tx MXene
ACS nano, v 10(3), pp 3674-3684
22 Mar 2016
PMID: 26909865
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
MXenes are a family of atomically thin, two-dimensional (2D) transition metal carbides and carbonitrides with many attractive properties. Two-dimensional Ti3C2Tx (MXene) has been recently explored for applications in water desalination/purification membranes. A major success indicator for any water treatment membrane is the resistance to biofouling. To validate this and to understand better the health and environmental impacts of the new 2D carbides, we investigated the antibacterial properties of single- and few-layer Ti3C2Tx MXene flakes in colloidal solution. The antibacterial properties of Ti3C2Tx were tested against Escherichia coli (E. coli) and Bacillus subtilis (B. subtilis) by using bacterial growth curves based on optical densities (OD) and colonies growth on agar nutritive plates. Ti3C2Tx shows a higher antibacterial efficiency toward both Gram-negative E. coli and Gram-positive B. subtilis compared with graphene oxide (GO), which has been widely reported as an antibacterial agent. Concentration dependent antibacterial activity was observed and more than 98% bacterial cell viability loss was found at 200 μg/mL Ti3C2Tx for both bacterial cells within 4 h of exposure, as confirmed by colony forming unit (CFU) and regrowth curve. Antibacterial mechanism investigation by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) coupled with lactate dehydrogenase (LDH) release assay indicated the damage to the cell membrane, which resulted in release of cytoplasmic materials from the bacterial cells. Reactive oxygen species (ROS) dependent and independent stress induction by Ti3C2Tx was investigated in two separate abiotic assays. MXenes are expected to be resistant to biofouling and offer bactericidal properties.
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Details
- Title
- Antibacterial Activity of Ti₃C₂Tx MXene
- Creators
- Kashif Rasool - Qatar Environment and Energy Research Institute (QEERI), Hamad Bin Khalifa University (HBKU) , P.O. Box 5825, Doha, QatarMohamed Helal - Qatar Environment and Energy Research Institute (QEERI), Hamad Bin Khalifa University (HBKU) , P.O. Box 5825, Doha, QatarAdnan Ali - Qatar Environment and Energy Research Institute (QEERI), Hamad Bin Khalifa University (HBKU) , P.O. Box 5825, Doha, QatarChang E Ren - Department of Materials Science and Engineering and A.J. Drexel Nanomaterials Institute, Drexel University , Philadelphia, Pennsylvania 19104, United StatesYury Gogotsi - Department of Materials Science and Engineering and A.J. Drexel Nanomaterials Institute, Drexel University , Philadelphia, Pennsylvania 19104, United StatesKhaled A Mahmoud - Qatar Environment and Energy Research Institute (QEERI), Hamad Bin Khalifa University (HBKU) , P.O. Box 5825, Doha, Qatar
- Publication Details
- ACS nano, v 10(3), pp 3674-3684
- Publisher
- American Chemical Society; Washington, DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000372855400072
- Scopus ID
- 2-s2.0-84961937725
- Other Identifier
- 991014970023804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology