Journal article
Antibacterial, anti-inflammatory and neuroprotective layer-by-layer coatings for neural implants
Journal of neural engineering, v 12(4), pp 046015-46023
08 Jun 2015
PMID: 26052137
Abstract
Objective. Infection, inflammation, and neuronal loss are common issues that seriously affect the functionality and longevity of chronically implanted neural prostheses. Minocycline hydrochloride (MH) is a broad-spectrum antibiotic and effective anti-inflammatory drug that also exhibits potent neuroprotective activities. In this study, we investigated the development of biocompatible thin film coatings capable of sustained release of MH for improving the long term performance of implanted neural electrodes. Approach. We developed a novel magnesium binding-mediated drug delivery mechanism for controlled and sustained release of MH from an ultrathin hydrophilic layer-by-layer (LbL) coating and characterized the parameters that control MH loading and release. The anti-biofilm, anti-inflammatory and neuroprotective potencies of the LbL coating and released MH were also examined. Main results. Sustained release of physiologically relevant amount of MH for 46 days was achieved from the Mg2+-based LbL coating at a thickness of 1.25 m. In addition, MH release from the LbL coating is pH-sensitive. The coating and released MH demonstrated strong anti-biofilm, anti-inflammatory, and neuroprotective potencies. Significance. This study reports, for the first time, the development of a bioactive coating that can target infection, inflammation, and neuroprotection simultaneously, which may facilitate the translation of neural interfaces to clinical applications.
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Details
- Title
- Antibacterial, anti-inflammatory and neuroprotective layer-by-layer coatings for neural implants
- Creators
- Zhiling Zhang - Drexel University School of Biomedical Engineering, Science and Health Systems , 3141 Chestnut Street, Philadelphia, PA 19104, USAJia Nong - Drexel University School of Biomedical Engineering, Science and Health Systems , 3141 Chestnut Street, Philadelphia, PA 19104, USAYinghui Zhong - Drexel University School of Biomedical Engineering, Science and Health Systems , 3141 Chestnut Street, Philadelphia, PA 19104, USA
- Publication Details
- Journal of neural engineering, v 12(4), pp 046015-46023
- Publisher
- IOP Publishing
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000358178900017
- Scopus ID
- 2-s2.0-84937469179
- Other Identifier
- 991014877866904721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Neurosciences