Journal article
Antibody Binding Is a Dominant Determinant of the Efficiency of Human Immunodeficiency Virus Type 1 Neutralization
Journal of virology, v 80(22), pp 11404-11408
Nov 2006
PMID: 16956933
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Primary and laboratory-adapted variants of human immunodeficiency virus type 1 (HIV-1) exhibit a wide range of sensitivities to neutralization by antibodies directed against the viral envelope glycoproteins. An antibody directed against an artificial FLAG epitope inserted into the envelope glycoproteins of three HIV-1 isolates with vastly different neutralization sensitivities inhibited all three viruses equivalently. Thus, naturally occurring HIV-1 isolates that are neutralization resistant are not necessarily more impervious to the inhibitory consequences of bound antibody. Moreover, the binding affinity of the anti-FLAG antibody correlated with neutralizing potency, underscoring the dominant impact on neutralization of antibody binding to the envelope glycoproteins.
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Details
- Title
- Antibody Binding Is a Dominant Determinant of the Efficiency of Human Immunodeficiency Virus Type 1 Neutralization
- Creators
- Xinzhen Yang - Department of Cancer Immunology and AIDS, Dana-Farber Cancer InstituteInna Lipchina - Department of Cancer Immunology and AIDS, Dana-Farber Cancer InstituteSimon Cocklin - Department of Cancer Immunology and AIDS, Dana-Farber Cancer InstituteIrwin Chaiken - Department of Cancer Immunology and AIDS, Dana-Farber Cancer InstituteJoseph Sodroski - Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute
- Publication Details
- Journal of virology, v 80(22), pp 11404-11408
- Publisher
- American Society for Microbiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000241821300051
- Scopus ID
- 2-s2.0-33750743141
- Other Identifier
- 991014878604904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Virology