Files and links (1)
Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Antibody-Dependent Enhancement of Severe Disease Is Mediated by Serum Viral Load in Pediatric Dengue Virus Infections
The Journal of infectious diseases, v 221(11), pp 1846-1854
11 May 2020
PMID: 32236481
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Low preexisting anti-dengue virus (DENV) antibody levels are associated with elevated disease severity. While antibody-dependent enhancement of dengue is thought to be driven by viral load, this has not been conclusively shown. We evaluated the association between preinfection anti-DENV antibody titers, viral load, and disease severity among 133 dengue cases in a Nicaraguan pediatric cohort study.
Viral load was quantified in acute-phase serum by real-time reverse transcription polymerase chain reaction and analyzed in relation to preinfection antibody titer (measured by inhibition enzyme-linked immunosorbent assay) and dengue severity, categorized using 3 definitions.
Higher viral load was significantly associated with dengue severity; for each increase of 1.0 log10 copies/mL, the odds of severe dengue increased approximately 50%, regardless of severity definition. Viral load at presentation and the odds of severe disease were highest among patients with low to intermediate preinfection antibody titers and lowest among those with the highest antibody titers. We showed the effect of preinfection antibody titer on disease severity was mediated by viral load for each of 3 dengue severity outcomes.
This study demonstrates the association between preinfection anti-DENV antibody titer, serum viral load, and disease severity, and provides evidence for the mechanism of antibody-dependent enhancement in dengue cases.
Metrics
Details
- Title
- Antibody-Dependent Enhancement of Severe Disease Is Mediated by Serum Viral Load in Pediatric Dengue Virus Infections
- Creators
- Jesse J Waggoner - Emory UniversityLeah C Katzelnick - University of California, BerkeleyRaquel Burger-Calderon - Sustainable Sciences InstituteJulia Gallini - Emory UniversityRenee H Moore - Emory UniversityGuillermina Kuan - Ministerio de SaludAngel Balmaseda - Sustainable Sciences InstituteBenjamin A Pinsky - Stanford UniversityEva Harris - University of California, Berkeley
- Publication Details
- The Journal of infectious diseases, v 221(11), pp 1846-1854
- Publisher
- Oxford University Press
- Grant note
- K08 AI110528 / NIAID NIH HHS P01 AI106695 / NIAID NIH HHS R01 AI099631 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000537458000015
- Scopus ID
- 2-s2.0-85084241792
- Other Identifier
- 991021448062604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology