Journal article
Antioxidant, anti-inflammatory and epigenetic potential of curcumin in Alzheimer's disease
BioFactors (Oxford), v 50(4), pp 693-708
Jul 2024
PMID: 38226733
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Alzheimer's disease (AD) constitutes a multifactorial neurodegenerative pathology characterized by cognitive deterioration, personality alterations, and behavioral shifts. The ongoing brain impairment process poses significant challenges for therapeutic interventions due to activating multiple neurotoxic pathways. Current pharmacological interventions have shown limited efficacy and are associated with significant side effects. Approaches focusing on the early interference with disease pathways, before activation of broad neurotoxic processes, could be promising to slow down symptomatic progression of the disease. Curcumin-an integral component of traditional medicine in numerous cultures worldwide-has garnered interest as a promising AD treatment. Current research indicates that curcumin may exhibit therapeutic potential in neurodegenerative pathologies, attributed to its potent anti-inflammatory and antioxidant properties. Additionally, curcumin and its derivatives have demonstrated an ability to modulate cellular pathways via epigenetic mechanisms. This article aims to raise awareness of the neuroprotective properties of curcuminoids that could provide therapeutic benefits in AD. The paper provides a comprehensive overview of the neuroprotective efficacy of curcumin against signaling pathways that could be involved in AD and summarizes recent evidence of the biological efficiency of curcumins in vivo.
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Details
- Title
- Antioxidant, anti-inflammatory and epigenetic potential of curcumin in Alzheimer's disease
- Creators
- Toufik Abdul-Rahman - Sumy State UniversityWireko Andrew Awuah - Sumy State UniversityTatiana Mikhailova - SUNY Upstate Medical UniversityJacob Kalmanovich - Drexel UniversityAashna Mehta - University of DebrecenJyi Cheng Ng - Universiti Putra MalaysiaMegan Ariel Coghlan - University of LouisvilleMarija Zivcevska - Liberty UniversityAlexander Tedeschi - College Station Medical CenterEmerson Costa de Oliveira - Univ Fed Minas Gerais, Fac Med, Belo Horizonte, MG, BrazilAkinchita Kumar - Lincoln Memorial UniversityEmiliano Cantu-Herrera - University of MonterreyMykola Lyndin - Sumy State UniversityKateryna Sikora - Sumy State UniversityAthanasios Alexiou - Novel Global Community Educ Fdn, Dept Sci & Engn, Hebersham, NSW, AustraliaAnwar Bilgrami - King Abdulaziz UniversityKhalid Mohammed Al-Ghamdi - King Abdulaziz UniversityAsma Perveen - King Saud bin Abdulaziz University for Health SciencesMarios Papadakis - Witten/Herdecke UniversityGhulam Md Ashraf - University of Sharjah
- Publication Details
- BioFactors (Oxford), v 50(4), pp 693-708
- Publisher
- Wiley
- Number of pages
- 16
- Grant note
- King Abdulaziz University
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001143484900001
- Scopus ID
- 2-s2.0-85182464749
- Other Identifier
- 991021901414404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism