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Journal article
Antirelapse Efficacy of Various Primaquine Regimens for Plasmodium vivax
Malaria research and treatment, v 2014(2014), 347018
01 Jan 2014
PMID: 25295216
Abstract
Background
. Efficacy of standard dose of primaquine (PQ) as antirelapse for
P. vivax
has decreased. We aimed to assess efficacy of different PQ regimens.
Methods
. It was an open label, randomized, controlled, parallel group, assessor blind study comparing antirelapse efficacy of 3 PQ regimens (B = 15 mg/day × 14 days, C = 30 mg/day × 7 days, and D = 30 mg/day × 14 days) with no PQ group (A) in
P. vivax
patients. Paired primary and recurrence samples were subjected to 3 methods: (i) month of recurrence and genotyping, (ii) by PCR-RFLP, and (iii) PCR sequencing, to differentiate relapse and reinfection. The rates of recurrence relapse and reinfection were compared. Methods were compared for concordance between them.
Results
. The recurrence rate was 16.39%, 8.07%, 10.07%, and 6.62% in groups A, B, C, and D,
respectively (
P
= 0.004). The relapse rate was 6.89%, 1.55%, 4%, and 3.85% as per the month of recurrence; 8.2%, 2%, 4.58%, and 3.68% (
P
= 0.007) as per PCR-RFLP; and 2.73%, 1.47%, 1.55%, and 1.53% as per PCR sequencing for groups A, B, C, and D, respectively. The concordance between methods was low, 45%.
Conclusion
. The higher recurrence rate in no PQ as compared to PQ groups documents PQ antirelapse activity. Regimens tested were safe. However, probable resistance to PQ warrants continuous monitoring and low concordance and limitations in the methods warrant caution in interpreting.
Metrics
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25 citations in Scopus
Details
- Title
- Antirelapse Efficacy of Various Primaquine Regimens for Plasmodium vivax
- Creators
- D. D. Rajgor - Department of Clinical Pharmacology, Seth G.S. Medical College and KEM Hospital, Parel, Mumbai 400 012, India.N. J. Gogtay - Department of Clinical Pharmacology, Seth G.S. Medical College and KEM Hospital, Parel, Mumbai 400 012, India.V. S. Kadam - Department of Clinical Pharmacology, Seth G.S. Medical College and KEM Hospital, Parel, Mumbai 400 012, India.M. M. Kocharekar - Department of Clinical Pharmacology, Seth G.S. Medical College and KEM Hospital, Parel, Mumbai 400 012, India.M. S. Parulekar - Department of Clinical Pharmacology, Seth G.S. Medical College and KEM Hospital, Parel, Mumbai 400 012, India.S. S. Dalvi - Department of Clinical Pharmacology, Seth G.S. Medical College and KEM Hospital, Parel, Mumbai 400 012, India Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine (DUCM), Philadelphia, PA 19104, USA National Chair Clinical Pharmacology, Indian Council of Medical Research (ICMR), Government of India, New Delhi 110 002, India Employee's State Insurance-Post Graduate Institute of Medical Sciences & Research (ESI-PGIMSR), Government of India, Mahatma Gandhi Memorial (MGM) Hospital, Dr. S.S. Rao Road, Parel, Mumbai 400 012, IndiaA. B. Vaidya - Drexel UniversityN. A. Kshirsagar - Indian Council of Medical Research
- Publication Details
- Malaria research and treatment, v 2014(2014), 347018
- Publisher
- Hindawi Publishing Corporation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Scopus ID
- 2-s2.0-84953754672
- Other Identifier
- 991019173796804721