Journal article
Antiviral activities of ISG20 in positive-strand RNA virus infections
Virology (New York, N.Y.), v 409(2), pp 175-188
2011
PMID: 21036379
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
ISG20 is an interferon-inducible 3′–5′ exonuclease that inhibits replication of several human and animal RNA viruses. However, the specificities of ISG20's antiviral action remain poorly defined. Here we determine the impact of ectopic expression of ISG20 on replication of several positive-strand RNA viruses from distinct viral families. ISG20 inhibited infections by cell culture-derived hepatitis C virus (HCV) and a pestivirus, bovine viral diarrhea virus and a picornavirus, hepatitis A virus. Moreover, ISG20 demonstrated cell-type specific antiviral activity against yellow fever virus, a classical flavivirus. Overexpression of ISG20, however, did not inhibit propagation of severe acute respiratory syndrome coronavirus, a highly-pathogenic human coronavirus in Huh7.5 cells. The antiviral effects of ISG20 were all dependent on its exonuclease activity. The closely related cellular exonucleases, ISG20L1 and ISG20L2, did not inhibit HCV replication. Together, these data may help better understand the antiviral specificity and action of ISG20.
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Details
- Title
- Antiviral activities of ISG20 in positive-strand RNA virus infections
- Creators
- Zhi Zhou - The University of Texas Medical Branch at GalvestonNan Wang - University of Tennessee Health Science CenterSara E. Woodson - The University of Texas Medical Branch at GalvestonQingming Dong - University of Tennessee Health Science CenterJie Wang - University of Tennessee Health Science CenterYuqiong Liang - The University of Texas Medical Branch at GalvestonRene Rijnbrand - The University of Texas Medical Branch at GalvestonLai Wei - Peking UniversityJoan E. Nichols - The University of Texas Medical Branch at GalvestonJu-Tao Guo - Drexel UniversityMichael R. Holbrook - National Institutes of HealthStanley M. Lemon - University of North CarolinaKui Li - University of Tennessee Health Science Center
- Publication Details
- Virology (New York, N.Y.), v 409(2), pp 175-188
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000286366800005
- Scopus ID
- 2-s2.0-78650295825
- Other Identifier
- 991019168538704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Virology